Numerical Analysis Of Microfluid State And Deformation Of Bone Tissue Engineering Scaffolds

As the development of tissue engineering and rapid prototyping technology, the research of artificial bone tissue engineering scaffold is also ongoing in-depth. In this paper, structure design of micro-channels in tissue engineering scaffold, flow state of micro-fluid in its internal micro-channels and scaffold deformation imposed by the pressure of fluid are studied and analyzed.Firstly, the internal structure of bone is analyzed, on this basis the internal structure of artificial bone is simplified and the structure model of three-dimensional micro-channels that has good vitro characteristics in scaffold is established.Secondly, the nutrient flow state in internal micro-channels of scaffold is simulated numerically by Fluent, CFX module in Ansys and the fluid dynamics module in Comsol3.2a, then results obtained are compared and analyzed. The problem of calculating that the fluid has no complicated boundary is simulated and calculated with Fluent.Then the scaffold deformation imposed by the pressure of nutrient in micro-channels is calculated and simulated by the use of Ansys with two-way and one-way FSI calculation method. Compared the results obtained by the two calculation methods, we can get the conclusion that when the velocity of nutrient is very low, we can use one-way FSI calculation method instead of two-way; Scaffold deformation is calculated with one-way calculation method while the perfusion velocity of nutrient and the structure of micro-channels are different, then results obtained is analyzed and compared. Maximum value of deformation is determined when the perfusion velocity of nutrient and the structure of micro-channels are different. Finally, it studied the two-phase flow characteristics of gas and liquid in rough micro-channel. It simulated two-phase flow pattern of nitrogen and water in rough micro-channel with VOF model in Fluent, then protracted the flow pattern chart of rough micro-channel. Compared it with the flow pattern chart of smooth micro-channel and the flow pattern chart obtained by Triplett's experiment, the validity of numerical simulation and experimental study are ensured.