Development Of Daidzein Dispersible Tablets

Daidzein (DZ) is a isoflavone, extracted from Pueraria. DZ has improtant physiological activity, but water-insoluble daidzein has low bio-availability. Solid dispersion technology was employed to increase its solubility and dissolution. Bioavailability was improved by changing the existing form, granularity and crystalline form of DZ.Using Poloxamer as the surfactant and polyvinylpyrrolidone (PVP) as the carrier, solid dispersions of DZ were prepared by solvent method. In order to characterize the prepared solid dispersions, X-ray power diffraction, Fourier transform infrared spectroscopy, as well as dissolution study were carried out. The results showed that the DZ solid dispersions could increase the dissolution rate of DZ.Daidzein dispersible tablets were prepared by combining with DZ solid dispersion and other excipients. Basing on the studies of the influence of formulation on the dissiolution and the disintegration, optimal formulation modified to dissolution drug over 8 h and distintegration was obtained by star point design-response surface optimization method and the optimal DZ dispersible tablets was screened. The best formulation includes microcrystalline cellulose (MCC) as the filler and Polyvinylpolypyrrolidone (PVPP) as the disintegrant. Daidzein dispersible tablets were prepared by direct compression method. The daidzein dispersible tablets of the best formulation were dispersed and disintegrated within 3 min. The HPLC method was used to study the content of the daidzein dispersible tablets. It was found that the dissolution rate of the DZ dispersible tablets was higher than the commercially available daidzein tablets.