| Objective:To observe the clinical effect of Qi Zhu Fei Xian Dcoction on patients with idiopathic pulmonary fibrosis (IPF) by taking Chinese medicine theoriesMethod:30 cases were included according to the diagnosis standard of IPF proposed by American Thoracic Society Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment International Consensus Statement2000 and th-e diagnosis standard proposed by Chinese Society Of Respiratory dise-ases in 2002. The patients taken Qi Zhu Fei Xian Decoction 6 months and observe the change of syndrome score, pulmonary function tests (D-Lco,VC,TLC), HRCT, arterial blood gas analysis (PaO2, PaCO2), SGRQ sco-re and 6-minute-walking-test (6-MWT) and and make a comprehensive eva-luation. The results were analysised by SPSS software.Results:1. syndrome score:the post-treatment total score of syndrome is obviously declined than pre-treatment, and has a significantly differences (P<0.01); the post-treatment score of gasp, shortness of breath and cough also declined (P<0.05); while the score of expectoration declined mildy, and there was no significant difference (P>0.05).In all, the result of syndrome score were 2 cases excellent (8%),16 cases effective(64%) and 7 cases invalid (28%), the total effective rate was 72%.2. Functional indexes:after treatment, the index of VC was signi-ficantly increased,and DLco, TLC, PaO2 or PaCO2 had no significant change(P>0.05)3. HRCT:There was 1 case better than before treatment (4%),16 cases stable (64%), and 8 cases invalid(32%), the total effective rate was 68%. 4. Quality of Life (QOL):activity component of SGQR scores and total scores all declined, and there was a significant differences between before and after treatment (P<0.05), and respiratory symptoms component and impact component of SGQR scores also declined, but there were no differences (P>0.05). the effect of 6MWT was improved, and the difference was statistically significant (P<0.05).5. comprehensive effect:there were 2 cases excellent (8%),17 cases effective(68%) and 7 cases invalid (24%), and the total effective rate was 72%.Conclusion:Qi Zhu Fei Xian dcoction not only improve the clinical symptoms of patients with IPF, such as gasp,shortness of breath and cough, and relieve patients'pain. And also improve VC, and delay the decline of TLC, DLco, and the worsening of arterial blood gas analysis and HRCT. Meanwhile it could obviously improve the quality of life. It is clear that there is a significant clinical effect on patients with the treatment of Qi Zhu Fei Xian Tang. |
