The Study On Microemulsion Transdermal Drug Delivery System Of Fluoxetine Hydrochloride

Depression is kind of affecticve disorder, it's caused by an imbalance of chemicals, along with other factors.The main feature is sadness. Fluoxetine hydrochloride(FLU) is a potent and highly selective inhibitor of serotonin uptake in nerve center., it's used for the treatment of depression in clinics. Microemulsion is used for drug carrier in this thesis , reduce the stimulation of gastrointestinal tract and first-pass metabolism, maintain constant plasma concentration effectively.The molecular weight of FLU is 345.8, and melting is 155～158℃. In the investigation of the pharmaceutical preformulation, drug's concentration in different solvents were determined by UV, and apparent partition coefficient was determined using shake flask method. The results showed the higher solvent's pH is, the lesser water solubility fluxetine reached . Similarly, the higher solvent's pH is, the more drug partition into oil than water.IPM,EO,GTCC were used for oils. Solutol SH15,Tween80,Cremophor RH40,Cremophor EL35 were selected as surfactants(Sf). 1,2-Propylene glycol,Glycerol,PEG400 were used for cosurfactant(CoSf). The pseudo-ternary phase diagrams were obtained with above oils,Sf,Cof and water. The effects of oils,Sf,Cof,Km,temperature,agitating velocity,agitating equilibrium time were investigated. The formulation and preparation process of blank ME and FLU ME were achievedBy using FLU as the model drug , the optimum formulation was selected by two indices: permeation coefficient(J),cumulative amount permeated per cm2(Q) used in the excised mice skin permeation experiment by sifting the ME constituents and theirs rations, The result of the optimum formulation percutaneous aborption experiment showed that the rate of drug release from microemulsion fitted well with Higuchi equation and there is a linear relationship between the cumulatice amount permeated(Q) and the time(t). The permeation coefficient is (135.57±11.2)μg.cm^-2.h^-1. The influential factor such as surficial temperature on the percutaneous permeation experiment was carried out.Then to study the physical chemistry property and stability of FLU microelulsion. The finging of physical chemistry property was: viscosity 3.256×10^-3Pa.s, reractive index 1.4185, mean diameter 40.5nm, Zeta electric 11.2mv. The stability of fluxetine hydrochloride microemulsion was good in the effect factor test under room temperature.