The Valuation Of P300 And The MoCA Scale, In The Diagnosis Of Cognitive Impairment After Cerebral Infarction

Objeets:1,Evaluation of P300 and the MoCA scale in the diagnosis of cognitive impairment after cerebral infarction; 2,preliminary study of cognitive impairment no-dementia characteristics after cerebral infarction.Methods: 90 cases(30 cases of each group,1 month, 3 months, 6 months) of cerebral infarction patients and the 30 cases of normal people were performed MoCA Scale, MMSE scale and P300 examination, compared of detected ratio . Further cerebral infarction paitietns based on a sensitive scale were divided into cognitive impairment group and non-cognitive impairment group. Then two group were compared with the normal group. Analyzed the relationship between different cerebral lesions and cognitive impairment, the characteristics of damage in some areas of cognitive function after cerebral infarction were analyzed..Results: In screening of cognitive impairment after cerebral infarction, event-related potential P300, MoCA scale were higher than the MMSE scale in detection rate, and there is statistical significant; P300 detection rate is slightly lower than the MoCA questionnaire, but no statistical significant. Further the cerebral infarction paitietns based on MoCA scale were divided into cognitive impairment group and non-cognitive impairment group.Between the two groups p300 latency and amplitude were statistically differences,.The two groups compared with the normal extension of p300 latency and amplitude were statistically significant difference. Different times after cerebral infarction (1 month, 3 months, 6 months )P300 examination and normal groups were statistically significant, the two groups of 3 months and 6 months were significant difference with 1 month group; but there were no significant differences, between 3and 6 months . In different parts of cerebral infarction, frontal lobe, temporal lobe, parietal lobe, basal ganglia, thalamus in the cognitive impairment group and normal group, were statistically significant difference,occipital lobe, cerebellum and brain stem between the two groups had no significant statistical difference. Between the cognitive impairment groups and the normal group in the implementation of visual-spatial execution ability, abstract, delayed recall were statistically differences ,in the implementation of naming, attention, language, no statistical difference.Conclusions: 1,Event-related potentials P300,MoCA scale is more sensitive than the MMSE scale, Event-related potentials P300 is more sensitive ,objective in cognitive impairment after cerebral infarction inspection and can be used as the dynamic observation of cognitive function,MoCA scale can be analyzed whether patients with certain areas of cognitive function impairment, combination of both can be more effective evaluation of cognitive function in patients. 2,Frontal lobe, temporal lobe, parietal lobe, basal ganglia, thalamus area of cerebral infarction are associated with cognitive impairments, occipital lobe,the cerebellum and brainstem infarction has nothing to do with cognitive impairment.3,After cerebral infarction the cognitive impairment of visual-spatial ability, abstract and delayed recall is significantly impaired.