Studies On Synthesis And Anticancer Activity Of Iodo-bridged Binuclear Platinum Complexes In Vitro

Cisplatin has become one of the most commonly used compounds for the treatment of a wide spectrum of human malignancies. However, cisplatin has severe toxicity and resistance. Under the classical structue-reactivity, many cisplatin analogues have been synthesized. What's more, "non-classical" platinum—binuclear and multinuclear platinum complexes have been synthesized, including iodo-bridged binuclear complexes. Eleven iodo-bridged binuclear complexes have been synthesized and characterized by elemental analysis, conductivity, IR, MS and 1HNMR spectra techniques. The cytotoxicity of the complexes was tested by MTT assay. The results show iodo-bridged binuclear complexes with aniline and methylaniline as ligands had better cytotoxicity than that of cisplatin or similar cytotoxicity to that of cisplatin against Bel-7402, HCT-8 and Hela cell lines.