Recently, it is the abuse of antibiotics and the wide use of the immunosupressive drugs, hormon and anti-tumor chemotherapy drugs that increases fungal infections and cancer incidence greatly.At the same time it also leads the fungal and tumors resistantance. So we need find new drugs with new broad-spectrums, low toxicity and high efficiency. Tiochromanone derivatives have a sort of sulfur atoms of heterocyclic and comprehensive physiological activities.In this paper the activities of new tiochromanone derivatives against fungal in vitro by Broth Microdilution were studied. The main pharmacological activities of one Thiochromanon Nitrogen Heterocyclic Ring Derivative in vitro were also reserched.The full text have three parts.Chapter one:The development of the tiochromanone derivatives, the methods for screening of antifungal drugs, acute toxicity test methods in mice were discussed in this paper.Chapter two:According the program M27-A and M38-A put forward by NCCLS,the activity of sixteen tiochromanone derivatives against nine kind of pathogenic fungi in vitro were evaluated. The trial fungi include Candida albicans, Cryptococcus neoformans, Trichophyton tonsurans,Trichophyton rubrum, Schenck's Sporothrix, Microsporum gypseum strains, Cladosporium Karnofsky, Aspergillus niger and Trichophyton floccus.Afterward the structure-activity relationship of these compouds were discussed.Chapter three:The main pharmacological activities of a copound which was named 2-hydrogen fluoride-6-sulfur and chromene [4,3-d][1,2,4] triazole and[1,5-a] pyrimidine was studied in mice. The study included acute toxicity, inhibition of H22 tumor growth, the extension of the life of H22 ascites-bearing mice and the impact on the leucocyte in mice.
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