| Objective:1. To investigate the distribution of arterial pathological changes in essential patients with hypertension.2. To study the relationship between cardiovascular risk factors and Pulse Wave Velocity in Patients with essential Hypertension and research the main factors which change arterial elasticity and stiffness.Methods:To select a cohort of 1671 patients with essential hypertension and 3179 non-hypertensive subjects who took an annual physical examination in the Third Xiangya Hospital and Xiangtan Hospital Health Care Center between Jan.2007 and Oct.2008 in random. All the research objects without any medication were documented on standardised case report forms, including brachial-ankle pulse wave velocity (baPWV), blood pressure (BP), height, weight, Waist circumference(WC), fasting blood sugar(FBS), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), creatinine (Cr), uric acid (UA) and so on. Their characteristics and the related factors of PWV were analyzed. We applied SPSS 16.0 for Windows to analyze the datas.Results:1. The patients with essential hypertension had significantly higher baPWV values(1689.59±331.83 cm/s vs 1311.42±171.20 cm/s, P=0.000) than the non-hypertensive subjects. The prevalence of the hypertensive patients with abnormal PWV values was significantly higher than that of the non-hypertensive subjects (83.60% vs 24.24%, P=0.000).2. Mean value and abnormal rate of baPWV in the different Classification of high blood pressure were significant differences (P=0.000), that is,Ⅲdegreehy hypertension (1984.70±425.60 cm/s,97.22%) was evidently higher thanⅡdegreehy hypertension (1788.04±314.17 cm/s, 93.54%), as the same as,Ⅱdegreehy hypertension was obviously higher than I degreehy hypertension(1590.32±274.49 cm/s,76.46%). Compared with the patients without complications, there were higher baPWV value and abnormal rate in the patients who combined with cardiovascular disease risk factors, that is, the agedness is higher than non-elderly (1928.28±371.97 vs 1572.80±234.19 cm/s, P=0.000.96.54% vs 77.27%,P=0.000), however, there was no difference between male and female(1694.33±333.93 vs 1678.91±327.11cm/s, P=0.381.84.28% vs 82.21%, P=0.283).3. Compared with the patients without those factors, there were higher baPWV value and abnormal rate in the patients with complications or cardiovascular risk factors, such as diabetes (1835.15±409.04 vs 1656.83±302.50cm/s,P=0.000.90.88% vs 81.96%, P=0.000), coronary heart disease(1985.38±395.35 vs 1665.88±313.87cm/s, P=0.000.92.97% vs 82.83%,P=0.002), hyperlipoidemia (1711.76±342.30 vs 1616.03±282.62cm/s,p=0.000.85.51% vs 77.26%, P=0.000), and obesity or abdomen obesity (1718.02±345.75 vs 1630.86±292.71 cm/s,p=0.000.86.00% vs 78.72%, P=0.000), as well as the smoking patients (1723.81±355.38 vs 1664.79±312.76cm/s, P=0.000.87.03% vs 81.17%, p=0.002). Multiple logistic regression analyses showed that Age, blood pressure, Waist circumference, TC, FBS, HDL-C, LDL-C, Cr, history of diabetes, coronary heart disease and smoking were independently associated with abnormal PWV, and age (r=0.598, P=0.000. OR=8.204,P=0.000), systolic blood pressure (r=0.566,P=0.000. OR=7.401, P=0.000) were most closely related to PWV, and TC (r=0.268,P=0.000. OR=2.170,P=0.000), FBS (r=0.228, P=0.000. OR=2.306, P=0.000), coronary heart disease (r=0.257, P=0.000. OR=2.742, P=0.002), history of diabetes (r=0.208,P=0.000. OR=2.192,P=0.000) were also more closely related to PWVConclusions:1. Arterial stiffness of hypertensive patients was significantly higher compared with that of healthy people, and PWV can be used as the indicator of atherosclerosis in patients with hypertension.2. Age, blood pressure, hyperlipidemia, hyperglycaemia, high serum creatinine, diabetes, coronary heart disease and smoking were as independent risk factors for abnormal PWV of the hypertensive patients, and Age, systolic blood pressure were the most major risk factors of baPWVV values. |
PDF Full Text Request