| OBJECTIVE:To investigate the antibiotic resistance of Staphyloccus aureus collected in our hospital in 2007 and 2008,and to guide the normative medication and preven the antimicrobile resistance increasing.METHODS:All Staphyloccus aureus strains were isolated from varies departments during the period from Jan.2007 to Dec.2008 in our hospital. Susceptibility testing was carryied out by means of a unified protocal method. Results were analyzed according to CLSI 2006 standard.RESULTS:In the total 281 clinical isolates of S. Aureus,127were meticillin-resistance S. Aureus(MRSA), and respectively 45.2%. There was no obvious difference in MRSA isolation rate between 2 years. The infection rate of MRSA was increasing along with the increase of age. The resistance rate of MRSA to penicillin, cephazolin, clindamycin, gentamicin, tobramycin, erythromycin, tetracycline, fosfomycin, ciprofloxacin, levofloxacin, moxifloxacin and rifampicin was significantly higher than meticillin-sensitiveness S.Aureus (MSSA). Howerver, the susceptibility rate to sulfamethoxazole had no significant difference in MRSA and MSSA. The susceptibility rate of MRSA to chloramphenicol, vancomycin, teicoplanin, linezolid, quinupristin/dalfopristin was still 100%. No vancomycin-nonsusceptible strain (vancomycin-intermediary Staphylococcus aureus, VISA and vancomycin-resistant Staphylococcus aureus VRSA) was found. The resistance rate of moxifloxacin went up significantly in 2008 (P<0.05)CONCLUSION:The resistance rate of MRSA to many kinds of antibiotics is still high. To control the infection, it is essential to strengthen the sterilization and insulation measures, and make reasonable use of antibiotics. |
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