| Objective:To evaluate the efficacy and safety of long-mu liquid in treatment of atopic dermatitis in youths and adults and analyze the quality of life impact of long-mu liquid in patients with atopic dermatitis. And study its possible mechanism furtherly.Method:A total of 122 patients,12 to 41 years of age, with atopic dermatitis were treated by long-mu liquid or Loratadine tablets combined with 0.1% Hydrocortisone Butyrate cream for 2 months in a randomized trial.1. Divided patients with atopic dermatitis according to Hanifin and Rajka diagnostic criteria into two groups randomly, which were Chinese medicine group and western medicine group.And then divided patients of Chinese medicine group into syndrome of wind-dampness stagnating skin group and syndrome of wind and dryness due to blood deficiency group according to symptoms and signs.2. The Chinese medicine group included 62 cases taking long-mu liquid 1 or 2 orally and topically twice a day for 2 months. The western medicine included 60 cases, taking Loratadine tablets orally once a night and smearing 0.1% Hydrocortisone Butyrate cream twice a day for 2 months. Component of long-mu liquid 1:Raw Os Draconis 30g, Calcined Concha Osterae 30g, Poria with peel 30g, Herba Lophatheri 15g, Component of long-mu liquid 2:Raw Os Draconis 30g, Calcined Concha Osterae 30g, Rhizoma Drynariae 10g, Fructus Kochiae 30g.3. Visits were scheduled on preliminary diagnosis (before treatment),1,2,4 weeks after treatment and the end of the treatment. Recorded the change of symptoms and the physical signs, including lesion area of skin, disease severity, pruritus degree, SCORAD score, dermatology life quality index, adverse reaction, recurrence rate, ect. Took photos for targeted skin lesions at every visit.4. Efficacy was evaluated by investigator observation and patient self-assessment before and after the therapy. Efficacy criteria refer to "scoring atopic dermatitis (SCORAD)" instituted by European Task Force on Atopic Dermatitis (ETFAD) and evaluation of quality of life refer to dermatology life quality index(DLQI).Result:1. Both Chinese medicine group and western medicine group experienced significant improvement respectively in the total scores of symptoms and signs including scores of lesion area of skin, scores of disease severity, scores of pruritus degree and SCORAD score (P<0.05).There was no significant difference between Chinese medicine group and western medicine group of the total scores of symptoms and signs(P>0.05). The symptoms and signs of patients of Chinese medicine group have been improved after 2 weeks of the treatment, which mainly manifested in disease severity and itching condition.The improvement of skin lesions area was not obvious. All symptoms and signs showed no marked changes over 8-weeks continuous treatment.Comparing with Chinese medicine group, patients of western medicine group improved rapidly, but continuous treatment could not demonstrate symptoms and signs were improved. After 2 months follow-up, among patients of Chinese medicine group there were 5 cases relapsed, with the recurrence time of (37.28±8.51 days), which was much longer than western medicine group. There was no significant difference between syndrome of wind-dampness stagnating skin group and syndrome of wind and dryness due to blood deficiency group of the total scores of symptoms and signs after 8-weeks treatment (P>0.05).2. The efficacy rates were 83.87% and 78.33% for Chinese medicine group and western medicine group respectively,with non-significance difference between them (P>0.05). The efficacy rates were 93.33% and 75% for syndrome of wind-dampness stagnating skin group and syndrome of wind and dryness due to blood deficiency group respectively, with non-significance difference between them (P>0.05).3. Both Chinese medicine group and western medicine group experienced significant improvement respectively in symptoms and feelings,daily activities,leisure and total DLQ scores,but there was no significant difference between two groups (P> 0.05). Both syndrome of wind-dampness stagnating skin group and syndrome of wind and dryness due to blood deficiency group experienced significant improvement respectively, with non-significance difference between them (P>0.05). Relevant analysis found that DLQ scores were positively related to the SCORAD scores(P<0.05).Conclusion:Long-mu liquid in the treatment of atopic dermatitis in youths and adults is effective and safe, with similar effect of Loratadine combined with 0.1% Hydrocortisone Butyrate cream. It can improve systemic symptoms and signs, reduce SCORAD scores and recurrence rate, ease itching with no significant side effects and low pay.2 weeks after treatment symptoms and signs can be improved. Long-term treatment by long-mu liquid can achieve a significant improvement which is superior to the patients who use western medicine. After treatment the quality of life of the patients is improved. Long-mu liquid in the treatment of Syndrome of wind-dampness stagnating skin is superior to syndrome of wind and dryness due to blood deficiency. At the same time DLQI scores are positively related to SCORAD scores. |
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