The Initial Approach Of MR Perfusion Weighted Imaging On Diagnosis And Therapeutic Effect Assessment Value Of Uterine Cervix Cancer

Purpose:The characteristic of TIC and the related parameters including ME, WIR, WOR and TTP were analyzed and compared between Uterine Cervix Cancer tissue and the control using the PWI method. The application value of PWI method for Uterine Cervix Cancer diagnose, pathological grading, pathological classification and the curative effect after chemotherapy was explored.Method:Magnetic resonance of pelvic cavity transverse and sagittal scanning, transverse DWI scanning, transverse T1WI Perfusion Imaging and enhancement scanning were applied in 52 cases with Uterine Cervix Cancer and 25 cases as control. The TIC of region of interest was recorded. "Basic T1 Perfusion" was used to analyze the TIC and the related parameters between Uterine Cervix Cancer tissue and the control. The perfusion parameters of Cervical cancer (UCC) and normal cervix, of the squamous carcinoma of the cervix, and of the adenocarcinoma of the uterine cervix, and the perfusion parameters in different pathological levels of cancer, as well as the perfusion parameters of 9 cases of cervical cancer patients before and after the chemotherapy were analyzed respectively.Result:(1) Rapid rise with gradual decline TIC predominated in the 52 cases with Uterine Cervix Cancer, exhibiting a notable upslope and a plateau after peaking. Among the 52 cases,40 cases showed rapid rise with gradual decline; 2 cases showed rapid rise and down; 10 cases showed rise slowly. In the 25 control cases,18 cases showed rise slow type,3 cases showed rapid rise with gradual decline,4 cases showed the type between the "rapid rise with gradual reduction" and "slow up". (2) ME, WIR, WOR of invasive carcinoma of cervix group showed significant increase compared with normal uterine cervix, carcinoma in situ of uterine cervix group, while TTP was significantly lower in invasive cervical cancer group than the normal uterine cervix, carcinoma in situ of uterine cervix group. ME, WIR, WOR and TTP of carcinoma in situ of uterine cervix of the cervix and the normal group showed no significant differences, the same result was found between cervical squamous cell carcinoma and adenocarcinoma.Compare the perfusion parameters of each other between Cervical squamous cell carcinoma of poorly, moderately and well differentiated groups:ME, WIR, WOR of well-differentiated group were significantly lower than poorly differentiated group, (P<0.05), while TTP of well-differentiated group was significantly higher. WIR of moderately differentiated group was significantly lower than that of poorly differentiated group. TTP of well- differentiated group was significantly higher than that of moderately differentiated group. ME, WIR, WOR and TTP of the rest groups showed no significant differences. In the group with UCC and chemotherapy:ME and WIR were significantly higher before chemotherapy than those after chemotherapy, while TTP delayed significantly after chemotherapy than before that, (P<0.05). WOR showed no significant differences before and after chemotherapy.Conclusion:MRI can reflect the pathologic features of the Uterine Cervix Cancer tissue and the control, which could be used to distinguish Uterine Cervix Cancer tissue and the normal tissue. The TIC and perfusion parameters can reflect the changes of signal and enhancing rate, therefore the characteristics of blood supply in Uterine Cervix Cancer tissue were also reflected, which could help with the etiologic diagnosis of Uterine Cervix Cancer. In addition, they can help with pathological grading of UCC and play an important part in the curative effect evaluation after chemotherapy.