| Objective to reseach on correlation between polymorphism of XPG gene (C-T) and therapeutic effect of oxaliplatin for advanced gastric cancer. To provide evidence of the treatment of advanced gastric cancer with oxaliplatin in clinical.Methods XPG genotyoin Of DNA, from peripheral venous blood for 92 advanced gastric cancer patients, which was detected with Real-time PCR. Evaluate efficacy after two cycle of chemotherapy by RICIST method in the study as well as add up the median time to progression. Compare whether there are differences between wild-type patients and the mutation ones in clinical efficacyResults The effect rates of the three genotypes are:C/C 51.09%(47/92), C/T 38.04% (35/92), and T/T 10.87%(10/92); while the disease contral rates of chemotherapy and the median TTP of C/C and T/T+C/T genotypes were 76.59%,6-month and 53.33%,4-month, respectively. Both of C/C group was higher.Conclusion XPG gene of wild-type patients are more sensitive than the mutation ones, which showed that there are correlation between XPG gene polymorphism and efficacy of oxaliplatin,and their test results can guide the choice of oxaliplatin chemotherapy for gastric cancer. |
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