The Changes Of Systemic Angiotensin System In Surgical Patients

Background and ObjectiveSkin and its appendages are a peripheral neuroendocrine organ, which play a two-way regulatory role between the brain and the body (skin). Moreover, it may not rely on the traditional central system to cause stress response. Study on the activity of body's stress hormone system is mainly contain:sympathetic-adrenal medullary system (SAMS) and hypothalamus-pituitary-adrenal axis (HPAS). In fact, it can not be ignored that renin-angiotensin system (RAS) is also belong to stress hormone system, and it closely related to SAMS and HPAS. For maintain homeostasis, Organism need a very complete and precise control system, namely nerve-Immune-endocrine regulatory network. The psychological stress is involved in nerve-Immune-endocrine network to regulate the activity of target protein, as an important role in the process of maintaining body homeostasis.Angiotensin system, as an important stress hormone system, was introduced in the process of psychological stress affected wound healing. The study will explore the material basis of psychological stress influence wound healing. There is no similar study at home and abroad.Clinical epidemiological investigation will be used to confirm that the role of psychological stress on wound healing.Methods To investigate the state anxiety of surgery preoperative patients and compare normal control groups, measure some important components (such as Ang I, ACE, and Ang II) of plasma angiotensin system in surgery patients, and compare related physiological index.1) To compare the state anxiety of patients before surgery and normal control groups by clinical epidemiological survey.2) To evaluate the levels of some important components (Ang I, ACE, and Angâ…¡) of plasma angiotensin system in states anxiety surgery patients and normal group, analysis the changes of these contents between preoperative and intraoperative.3) To observe heart rate, blood pressure and other physiological indexes of surgical patients in anxiety with music therapy.Results1. There is significantly different in state anxiety between the patients of plastic surgical preoperative and normal control group by clinical epidemiological inquiry.2. The levels of component of plasma angiotensin system (Ang I, ACE, and Ang II) of operative patients in state anxiety were significantly increased than that of the normal control group. These contents have different changes between preoperative and intraoperative. There were no significant changes of Ang I and Angâ…¡levels, but statistically significant changes of ACE.3. Music therapy can improve the state anxiety of surgical patients, such as heart rate, systolic pressure and pain were significant decreased, and wound heading time have not significantly change.ConclusionsSurgery is a serious stressor and a cause of anxiety for the patients, particularly, the plastic cosmetic surgery patients. Some important components in plasma angiotensin were significant changed. Music therapy could improved anxiety, angiotensin system might be involved in the regulation of psychological stress.