| ObjectiveThis study randomized patients with coronary disease by percutaneous coronary angioplasty (PCI) after application of Chinese and western medicine (plus Xuesaitong injection), only western intervention efficacy clinical hemorrheology, blood lipids (total cholesterol, total triglyceride, low density lipoprotein, high density lipoprotein), hemorheology (blood viscosity, erythrocyte variable line index, erythrocyte aggregation index), platelet aggregation and thromboxane A2 (TXA2) Change of relevant indicators to evaluate Xuesaitong injection after PCI in patients with coronary heart disease treatment.MethodsRandomized single blind controlled method,125 cases met the clinical diagnostic criteria for coronary heart disease were the study.125 patients admitted to hospital after the verdict, enteric-coated aspirin 100mg qd, metoprolol 12.5mg Bid, saline 250ml+L-carnitine (Reca) 3g+ cAMP-DTPA injection (meglumine) 180mg intravenous infusion qd.All patients admitted to hospital on day 5 or 6 days coronary angiography (CAG), of which 27 cases without making CAG, CAG excluding 18 cases, CAG 80 cases diagnosed. According to results of coronary artery stenosis, CAG after diagnosis divided into two groups:one group observed a group of 37 patients (coronary artery stenosis≥75% ofline PCI), including 20 cases in the control group 1 (simple with Western medicine),17 patients were treated Group 1 (Western+Xuesaitong injection); another group observed two groups of 43 patients (coronary artery stenosis≥50% but<75% of the non-line PCI), of which 22 cases of control group 2 (simple with Western medicine),21 patients treated group 2 (Western+Xuesaitong injection).Control group 1 to the original regimen based on the use of clopidogrel 75mg qd, treatment group 1 in the original regimen based on the use of clopidogrel 75mgqd, saline 250ml+Xuesaitong 0.6g intravenous injection. the control group 2 continue to the original program.the treatment group 2 in the original program treatment plus saline 250ml+Xuesaitong 0.6g intravenous injection.Xuesaitong injection course of treatment were 15 days.If the combination of hypertension and or diabetes, it is used with antihypertensive drugs and or hypoglycemic drugs, such as chest pain patients during the treatment, the drugs can not relieve those who are sublingual nitroglycerin 0.5mg.The main targets include:determination of blood lipids before and after treatment (total cholesterol, total triglyceride, low density lipoprotein, high density lipoprotein) levels; determination of hemorheology (blood viscosity, erythrocyte deformation index, erythrocyte aggregation index) changes; determination of platelet aggregation and thromboxane A2 (TXA2) changes.Refer to the Ministry of health the TCMS study guide drug assessment criteria, set the following security evaluation criteria. Level 1:safety, without any adverse reaction; Level 2:relatively safe, if adverse reactions, without doing any processing, you can continue to medicine; Level 3:There are security issues, there is moderate adverse reactions, can continue to medicine; Level 4:Adverse reactions due to the termination of experiment.ResultCAG confirmed 80 cases of coronary heart disease, observed a group of 37 patients (coronary artery stenosis≥75% of line PCI), including 20 cases in the control group 1 (simple to use western medicine),17 cases of treatment group 1 (Western+Xuesaitong injection), two groups of clinical data in the general hospital, coronary lesions, the degree of stenosis was no significant difference (P>0.05), two groups were comparable. Observed 43 cases of the two groups (coronary artery stenosis≥50% but<75 did not line PCI), of which 22 cases of control group 2 (simple with Western medicine),21 cases of treatment group 2 (Western Canada Xuesaitong Injection) two groups of patients in the hospital clinical characteristics, coronary lesion, degree of stenosis was no significant difference (P>0.05), two groups were comparable.Treatment group 1TC, TG, LDL-C before and after treatment was statistically significant (P<0.05). Treatment group 1 and control group 1 TC between the two groups after treatment was statistically significant (P<0.05), treatment group 1 after treatment with the control group 1 TG between the two groups was statistically significant (P<0.05). The second observation group of the result was the same as the first observation group.Role in the regulation of hemodynamics, treatment group 1, high-shear blood viscosity, erythrocyte deformation index before and after treatment was statistically significant (P<0.05). Treatment group and control group 11 RBC deformability index after treatment between the two groups was statistically significant (P<0.05). Treatment group 2, blood viscosity, high shear, low shear blood viscosity, erythrocyte deformation index, erythrocyte aggregation index before and after treatment was statistically significant (P<0.05). Treatment group 2 and control group 2 after treatment of high blood viscosity shear, low shear blood viscosity, erythrocyte deformation index, erythrocyte aggregation index between the two groups was statistically significant (P<0.05).To improve the role of TXA2 and platelet aggregation, the treatment group 1 before and after treatment with the control group 1 TXA2, platelet aggregation was significantly more (P<0.05), treatment group 1 and control group 1 TXA2 after treatment between the two groups was statistically sign-ificance (P<0.05). Treatment groupl and control group 1 platelet aggregation after treatment between the two groups was statistically significant (P<0.05) The second observation group of the result was the same as the first observation group.Xuesaitong injection was no drug side effects.ConclusionBy Xuesaitong injection incoronary heart disease the fficacy of postoperative PCI observation, that is, Integrative Medicine (plus Xuesaitong injection) and western medicine, to evaluate Xuesaitong injection PCI in patients with coronary heart disease postoperative heart lipids, bloo rheology, platelet aggregation and other effects. The results showed that the treatment group more effective in regulating lipid metabolism and improving blood rheology, prevent thrombus formation, improve microcirculation and reduce the stenosis rate. Xuesaitong injection was no drug side effects.
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