| Cancer is one of the common diseases which harm people's health and lives seriously. Early and clear diagnosis plays a critical role in guiding treatment of malignant tumor. Imaging examination is an important means for diagnosis of malignant tumors. The result is often a direct impact on the choice of clinical treatment and prognosis. The current imaging studies(ultrasound, X-ray, CT, MRI, etc.) through morphological image to achieve, which can not reflect micro-changes in tumor tissue. So developing the treatment is delayed and blindness. MR functional imaging break through the constraint of the conventional images and show up ascendancy in qualitation, the judgement of malignant degree and curative effect of tumors from biology, physiology and biochemistry. DWI is one of the MR functional imaging and show physiological and pathological changes through measuring the microscopic molecular movement of water in the tissues. This technique can provide more information for guiding the continued treatment plans and lasting life time. At present, most of the researches in diagnosis of tumor using DWI and ADC value is major of brain and rectal tumors. Many scholars has studied in differentiating benign and malignant tumors in liver through DWI, but the research of identification different pathological types of liver cancer using DWI and ADC is rare.Objective: In this experiment, we discuss the changes and significance of mean apparent diffusion coefficient(ADC) value in and provid valuable evidences for judgement effect of diagnoses of liver cancer in the early stage. Methods: 26 patients ( 21 male patients and 5 female patient, aged 28 to 65 years, mean 54 years) with liver malignant Tumor.All these were confirmed by pathological examination. 14 patients with hepatocellular carcinoma,5 patients with cholangiocellular carcinoma,7 patients with hepatatic metastatic neoplasms.Before treatment conventional MRI and DWI were performed in 26 patients, respectively. To choose five(region of interests, ROIs) in ADC map randomly and measure the ADC values of tumor tissue. If there are multiple lesions in a case, only selected the results corresponding to the pathological lesions to measure.ROIs get out of zone of necrosis, blood vessel, bile vessel in order to avoid error of measurement. The ADC values of liver were obtained in the same method. T2WI image were loaded in Argus browser and compute tumor volume through the software. To compare ADC values of patients with different pathological types of liver lesions and the surrounding normal liver tissue using Paired-Sample T Test. If P<0.05, the difference was significant. Application of single-factor analysis of variance, for different types of liver pathology of ADC values of malignant lesions in pairwise comparison between groups.If P<0.05, the difference was significant. Results:2.1 Different types of liver lesions compared with the surrounding liver tissueThe average ADC value of tumor tissue of the patients with hepatocellular carcinomathe(0.85±0.13)×10-3mm2/s,if the value b denfined 50,400和1000 s/mm2. The average ADC value of liver tissue i(s1.01±0.20)×10-3mm2/s,t=9.142,P=0.000<0.05. The results showed that they had significant statistically between them. The average ADC value of tumor tissue of the patients with cholangiocellular carcinoma is (0.88±0.12)×10-3mm2/s, The average ADC value of liver tissue is (0.96±0.20)×10-3mm2/s,t=6.880,P=0.003<0.05. The results showed that they had significant statistically between them. The average ADC value of tumor tissue of the patients with hepatatic metastatic neoplasms is (0.93±0.07)×10-3mm2/s, The average ADC value of liver tissue i(s0.98±0.20)×10-3mm2/s,t=2.998,P=0.037<0.05. The results showed that they had significant statistically between them.2.2 comparison with the different types of liver cancerThe average ADC value in Hepatocellular carcinoma and liver metastases have significant statistically at the same value b. Conclusion:Different pathological types of liver cancer have different feature at different DWI. It is helpful for Identification in liver malignant tumors. through quantitative analysis of the ADC values, it can Provide an important basis for Qualitative diagnosis of liver cancer.
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