Clinical Therapeuc Efficacy With Huangqizhimushenqi Granula For Diabetic Kidney Disease With Qi And Yin Vacuity

Objective:By observing the changes of 24h urine protein (UP-24), serum C-reactive protein (CRP), fibrinogen (Fib) levels, as well as diabetic retinopathy (DR) the change " Huangqizhimushenqi Granula " diabetic kidney disease (DKD) the 3rd or 4rd stage with qi and yin vacuity, the clinical efficacy and to explore its possible mechanism of DKD; with a view to DKD early prevention and treatment of renal dysfunction in patients with DKD slow progress in reducing the duration and in patients with DKD 5th stage into the replacement treatment.Methods:Select treatment in Nanjing Military Region, Fuzhou General Hospital, Department of Nephrology, Department of Endocrinology, and Chinese medicine outpatient clinic of the Qi and Yin vacuity the 3rd or 4th stage DKD 60 patients were randomly divided into control groups with 30 patients and treatment group of 30 patients treated with Huangqizhimushenqi Granula in the control group to the conventional Western medicine treatment to 8 weeks as a course of treatment, were observed therapy Qi and Yin vacuity the 3rd or 4th stage DKD, the clinical efficacy and UP-24, CRP,Fib levels and DR.Results:(1) groups before and after treatment the clinical symptoms of traditional Chinese medicine. treatment group was more effective than the control group (p<0.05). The treatment group response rate was 96.7% while the control group response rate was 73.3%. (2) 24h urine protein after treatment compared with pre-treatment significantly improved (p<0.05), treatment group 86.7% in the control group was 76.7%, no significant difference in efficacy of the two groups (p>0.05). (3) Crp and fib level than before treating are falling (p<0.05).In the CRP before and after treatment the difference between the two groups, UP-24 margin, Fib were significantly difference among the correlation (p<0.05).(4) DKD generally associated with the occurrence of DR, DR situation improved significantly after treatment (p<0.05), the treatment group was 87% in the control group response rate was 82.6%. The therapeutic effect was no significant difference (p>0.05). (5) inadvertently during treatment, liver and kidney dysfunction, no electrolyte imbalance.Conclusions:(1) After treatment, clinical symptom score, UP-24, CRP, Fib, and DR conditions better than those before treatment. (2) groups of UP-24, CRP, Fib difference before and after treatment there is significant correlation. (3) instructor experience side, " Huangqizhimushenqi Granula " treatment Qi and Yin vacuity DKD 3rd or 4th stage, can significantly alleviate the symptoms, signs, can significantly improve its curative effect, the use of safe, non-obvious side effects, it is worth popularization and application.