Plasma Carbon Monoxide And Hydrogen Sulfide In Patients With Essential Hypertensive

Objective To study the implication of carbon monoxide (CO) and hydrogen sulfide (H2S) in essential hypertensive patients.Methods A total of 85 essential hypertensive patients were enrolled in this study and divided into 3 groups according to hypertension grouping criteria. All of them have been stopped from taking hypotensor and antilipemic for over one month or never, such circumstances bases on the ignoring of secondary hypertension, diabetes mellitus, coronary heart disease, hyperlipemia, etc. A total of 27 healthy were also enrolled as comparison. Plasma CO content and H2S concentration were determined in all patients and controls.Results①Compared with controls, plasma CO level have no marked difference between grade 1 and controls([18.6±1.9)v(s21.07±2.44)mmol/L,P>0.05], but in the grade 2 and 3 was significantly lower [(15.4±1.4),(12.5±1.7)mmol/L vs (21.1±2.4)mmol/L,P<0.05];②All of plasma H2S level in the three groups are lower than controls[(43.7±1.4),(37.6±1.8),(26.7±1.3)vs(51.4±1.4)mmol/L,P<0.05];③Plasma CO and H2S decrease with the increasing of blood pressure and they are positive correlation(r=0.627,P<0.05) in essential hypertensive patients.Conclusion As a signaling gasotransmitters, plasma CO and H2S might play important roles in the pathogenesis and development of hypertension.