Research And Application Development Of RGD-based Antithrombotic And Thrombolytic Agents

Thrombosis is a common clinical problems,seriously threatening people's health. How to produce better antithrombotic and thrombolytic agents with variable mechanisms has ever beening a hot tissue. The connect of fibrinogen and activated platelet glycoprotein IIb/IIIa (GPIIb/IIIa) receptor serves as the terminal common pathway in platelet aggregation and plays an important role in the formation of thrombus.The RGD motifs in fibrinogen which serving as a special ligand for GPIIb/IIIa receptor can target to the activated platelet at the thrombotic sites.Other elements with RGD motif can block the contact of fibrinogen and GPIIb/IIIa receptor specificially. Thus, these antithrombotic and thrombolytic agents based on RGD have being widely investigated. Partial agents have already been widely applied clinically.Some of them are undergoing experiments in-vitro or on animal and also have a good respect. This review will describe the research and application development of these RGD-based agents.