To Study The Relationship Between The Cerebral Arteriosclerosis And The Abnormal Alteration Of Blood Lipids And Hemorheology

Objective:To study the abnormal alteration of blood lipids and hemorheology in objects with CAS(Cerebral artery atherosclerosis) who were diagnosed by TCD(Transcranial Doppler ultrasonography) test, and expect the results could play a role in the diagnosis and prevention of CAS.Methods:Total of 345 cases studied, according to the TCD diagnostic criteria of cerebral arteriosclerosis ,we can divider all the cases into the observation group (cerebral atherosclerosis group) and control group (normal cerebral arteries), which observation group of 135 cases; control group of 210 cases. Detailed history and standard blood pressure measurement, application of the company's clinical and biochemical Olympus AU5400 analyzer for blood lipids, Succeeder company's automated blood rheometer SA-9000 for hemorheology, and using the DWL company's DWL2000- x1-type TCD to measure relevant parameters of intra/extra cranial artery.Organize and use of EXCEL and SPSS13.0 statistics above measured data, respectively observed with the control group and blood lipid changes related to indicators of the level of t test; using chi-square test for two groups the proportion abnormal blood lipid and blood rheology comparison; the relationship between the relevant parameters of atherosclerosis and blood lipid /hemorheology was analyzed by Multivariate Logistic regression.Results:1. Compared the index of mean serum lipid levels between observation group and control group, to the observation group for the TC (5.90±0.76 mmol / L), TG (1.47 (0.93) mmol / L), LDL-C (3.49±0.77 mmol / L), and HDL-C (1.48±0.40 mmol / L) ;and in the control group, TC (4.71±0.70 mmol / L), TG (1.4 (0.9) mmol / L), LDL-C (2.44±0.63 mmol / L) and HDL-C (1.30±0.34 mmol / L) , TC, HDL-C, LDL-C significantly (P <0.001), and TG showed no significant difference (P = 0.087> 0.05).2. The proportion of abnormal blood lipid indexes the two groups compared (study group% VS control group%): TC (88.89 VS 11.43), TG (37.04 VS 31.90), HDL-C (1.48 VS 7.14), LDL-C (37.78 VS 2.38) . Including TC, LDL-C and HDL-C significantly statistical difference (P <0.001), while the TG was no significant difference (P = 0.326).3. Observation group and control group the mean blood rheology compared (study group VS control group), in addition to Hct (0.42±0.04 VS 0.43±0.04) and significantly lower (P <0.05), the observation group, all other indicators higher than controls, respectivelyηbh (mPa ? S) (3.92±0.45 VS 3.88±0.41),ηbm (mPa ? S) (4.68±0.57 VS 4.61±0.50),ηbl (mPa ? S) (19.10±2.94 VS 18.64±2.75),ηrl (41.87±4.92 VS 40.18±4.58),ηrh (5.96±0.64 VS 5.76±0.58),ηp (mPa ? S) (1.39±0.15 VS 1.39±0.08), AI (4.87±1.44 VS 4.82±0.45), RI (4.35±0.46 VS 4.17±0.47). Including IR,ηrl,ηrh three indicators were significantly (P <0.05), the other five markers of hemorheology was no significant difference (P> 0.05).4. Observation group and control group the proportion of abnormal hemorheology indexes compared (study group% VS control group%):ηbl (37.04% VS 26.19%), the difference was statistically significant (p <0.05). The other indexes showed no statistically significant5. Multivariate Logistic regression analysis: TC andηrl have a significant effect on the incidence of atherosclerosis, the OR values were: 43.217,8.02,respectively.Conclusions:1. Both the serum mean lipid levels of TC and the LDL-C and the abnormal ratio in control group were higher than the control group, suggesting that it plays a major role in atherosclerosis.2. Hemorheology of the observation group inηbl,ηrl,ηrh, IR and other indicators higher than the mean or the abnormal cases, suggesting it also plays an important role in atherosclerosis.3. hyper-TC, and hyper-ηrl are risk factors for cerebral arteriosclerosis.