The Clinical Study Of Serum Uric Acid Level In Patients With Chronic Heart Failure

Objective:To investigate the relationship between serum uric acid level and left ventricular ejection fraction (LVEF) in patients with chronic heart failure. Methods:Five hundred and twelve patients with chronic heart failure were analysed retrospectively in our hospital between January 2007 and June 2009. Among five hundred and twelve patients with chronic heart failure, one hundred and ninety-six cases accorded with inclusion criteria. The inclusion criteria is that all of the patients accorded with NYHA class I-IV and were between 35 and 65 years old as well as serum BUN of the patients was less than 7.1 mmol/L, serum Cr of the man patients was less than 106umol/L and the women patients was less than 97umol/L. Gout, renal dysfunction induced by primary or secondary factors, heart or vascular's malignant tumor and congenital malformation, use of drugs (diuretics was excluded) which effected uric acid metabolism were excluded. According to the different LVEF, the subjects were divided into four groups:Group A: LVEF≥50% 30cases; Group B:LVEF 40%-49% 30cases; Group C:LVEF 31%-39% 30cases; Group D:LVEF≤30% 30cases, finally, one hundred and twenty patients were included in our study. The patients in this study included 76 men (mean age 53.71±7.27 years old) and 44 women (mean age 56.36±6.70 years).51 cases were Han nationality and 69 cases were Uygur nationality. Each patient recived echocardiographic examine, serum uric acid level, BUN and Cr measurements.Serum uric acid level, LVEF and left ventricular end-diastolic diameter (LVEDD) were analysed. Results:There were significant differences in four groups regarding serum uric acid level (P<0.01=(group A:266.43±55.22 umol/L, group B:326.58±85.71 umol/L, group C:423.93±125.52 umol/L, group D:456.99±133.96 umol/L).Serum uric acid level was inversely related to LVEF (P<0.01, R=-0.551). With a progressive decrease in LVEF, serum uric acid level increase significantly. In addition, serum uric acid level was positively related to LVEDD(P<0.01, R=0.485). With a progressive increase in LVEDD, serum uric acid level increased significantly. Conclusion:Serum uric acid level increase maybe can predict deterioration of cardiac function.