The Investigation For Related Genes And Antibodies Of SLE Patients And Their Progenies

Objective To investigate the risk of children, who were born by paracmastic Systemic Lupus Erythematosus patients, suffering from Systemic Lupus Erythematosus, at the aspects of genes,autoantibodies and electrocardiogram.Methods Appling Real Time-PCR technology to detect the HLA-DRB1, DQA1, DQB1 alleles of 14 Systemic Lupus Erythematosus cases, the cases children and 20 healthy controls, to detect the ENA spectrum of all income groups with Aumont blot, do conventional ECG to offspring.Results Systemic Lupus Erythematosus patients with DQA1*0102 allele frequency was significantly higher than healthy controls (RR=2.02,P=0.0357<0.05), DRB1*1501, DRB 1*0301, DQB 1*0602 allele are no significant different between the two groups; Systemic Lupus Erythematosus patients with DQB1*0602 allele frequency was significantly higher than that of their offspring group (RR=2.06,P=0.0375<0.05) DRB1*1501, DRB 1*0301, DQA1*0102 allele are no significant different between the two groups; offspring with DQA1*0102 allele frequency was significantly higher than healthy controls (RR=2.14, P=0.0175<0.05), DRB1*1501, DRB1*0301, DQB1*0602 allele are no significant different between the two groups. Systemic Lupus Erythematosus patients appear multiple autoantibodies easily, healthy control group were detected four kinds of low-positive autoantibodies SSA, SSB, dsDNA, Ro-52. The frequency of SSA and dsDNA were higher than healthy controls (P< 0.05), the frequency of SSB and Ro-52 were higher than healthy controls (P> 0.05); No kinds of antibodies were detected in offspring. One cases of 14 children has premature ventricular beat, and complete right bundle block, three cases has sinus arrhythmia and the surplus appear normal ECG.Conclusion HLA-DQA1*0102 allele is one of the susceptibility genes of Systemic Lupus Erythematosus, which has a certain genetic susceptibility. The susceptibility of DQB1*0602 is needed to be confirmed with larger samples researching. DRB1*0301 and DRB1*1501 have no significant correlation with SLE. The risk of Systemic Lupus Erythematosus patients' progeny, who were born by paracmastic Systemic Lupus Erythematosus patients after systemic theraphy achieving remission, suffering from Systemic Lupus Erythematosus is not significant,at the aspects of genes,autoantibodies and electrocardiogram.