| Definition:Allergic rhinitis (AR) is a chronically reactive inflammation of the mucous membrane lining the nose involving many kinds of immune cells and cytokines because of the discharge of media (mainly histamine) mediated by IgE after specific individuals contact allergen. According to the outbreak time, it can be divided into two categories:seasonal and perennial. The former is caused by seasonal sensitizers, mainly pollen, and the latter is caused by perennial sensitizers.Purpose:(1)Compare with Western. medicine. Appraise the clinical effect of the prescription through the way benefiting vital energy and warming yang to treat the allergic rhinitis which is the lung and splenasthenic cryosyndrome. (2)Through measure the blood-serum IL-4,IFN-γlevel of the patients, who are the allergic rhinitis patients of the lung and splenasthenic cryosyndrome. Compare the prior treatment and the post-treatment. Evaluate the the clinical effect of the prescription through the way benefiting vital energy and warming yang to treat the allergic rhinitis which is the lung and splenasthenic cryosyndrome. (3) Approach the principle and the immunoregulatory dependability, by operating the way of benefiting vital energy and warming yang to cure the AR of lung and splenasthenic cryosyndrome.Method:Select 40 overview targets which fit the internalize standard, and select 5 health people to contrast. Distinguish the overview targets to two sets at random. The group of the traditional Chinese medicine oral application with the prescription by benefiting vital energy and warming yang; The group of Western medicine oral application with the Cetirizine. After four weeks, adopt the comparison method of self-circa and inter-contrast. Observe the change of the case symptom integration, and the amphi-sign. Draw-off 2ml venous blood of the 40 clinical research contain be cured before and after, and 5 blank overview targets. (each group has 20 overview targets, and 5 blank overview targets.) To separate the peripheral blood monouclear cells(PBMC), then to stimulate and activation the T cells extraorgan. To survey and evaluate the IL-4,IFN-γlevel of the PBMC.Result:The group of the traditional Chinese medicine been post-treatment:excellence 8 pou, utility 11 pou, inefficacy 1 pou. Super-utility rate is 95%, excellence rate is 40%. Amphi-sign like the lumbus and knee acidum and feeble,the chilly and pa-leng improve obviously. The group of Western medicine:excellence 4 pou, utility 13 pou, inefficacy 3 pou. Super-utility rate is 85%, excellence rate is 20%. The amphi-sign like the lumbus and knee acidum and feeble,the chilly and pa-leng hardly any improved. It explains the two drugs have therapeutic action, and effective power is high. But we find that the group of the traditional Chinese medicine is excellence than the Western medicine by comparing the excellence power. Meanwhile the amphi-sign like the lumbus and knee acidum and feeble,the chilly and pa-leng always manifest to the Western medicine.The IL-4 level which fit the internalize standard are higher than the blank group obviously. The IFN-γlevel are lower than the blank group obviously. After medicate, The IL-4 level of the the traditional Chinese medicine group of benefiting vital energy and warming yang are lower than the group of the Cetirizine. The IFN-γlevel step up and get close to the group of Western medicine, which explains that the therapeutic efficacy of the traditional Chinese medicine has an advantage than the Western medicine. Surely, these two ways of treatment can improve allergic rhinitis obviously, especially the traditional Chinese medicine.Two observe targets' blood-serum of IL-4,IFN-γlevel compare between prior treatment and post-treatment, P<0.01, which has conspicuous statistical significance. To explain that the traditional Chinese medicine of prescriptions of benefiting vital energy and warming yang, and the Western medicine of Cetirizine both are active drugs. They can cut down the blood-serum of IL-4 level, and advance the blood-serum of IFN-γlevel. They can improve immunity level. But the group comparison:explain that the IL-4 lower level of traditional Chinese medicine is outweigh than the Western medicine, P<0.01, which has conspicuous statistical significance. Explain that treatment the AR, and improving the AR's pathogenetic immunology found of Thl/Th2 unbalance, the traditional Chinese medicine of prescriptions of benefiting vital energy and warming yang has the dominance than the Cetirizine.
|
PDF Full Text Request