Clinical Research On The High Risk Factors For Osteoporosis And The Characters Of Bone Metabolism In Eldly Hospitalization Patients

PurposeThe purpose of this study was for screening the risk factors of osteoprosis in eldly hospitalization patients.And to investigate the alteration of bone metabolism and factors in eldly patients with chronic obstructive pulmonary diseases(COPD),type 2 diabetes mellitus(2DM).we try to find high risk population of osteoprosis, then by clinical intervention, to offer available proof for second level prevention and then reduce osteoporotic fracture.MethodsFirst, 270 patients in pationsgerontal department were random selected as study object, to observe age, sex, bone mass index(BMI), weekly intake of milk, age at menarche, if not take calcium and vitamin D, postmenopausal years, and number of births,smoking and check the bone density of calcaneus by using quantitative ultrasound. we mainly want to screen the risk factors of osteoprosis in eldly hospitalization patients .Then questionnaires survey was carried out in the 400 patients who were random selected, and then by reviewing the case history, 212 patients that consistent with the disease standardization were screened. And follow then, the index of bone metabolism was detected in the 212 patients'serum, which include anti-tartaric acid acid phosphatase-5b, osteocalcin, parathormone; parathyroid hormone, 25-Hydroxyvitamins D. 70 healthy aged were selected from medical examination center as the control group,they need to check above-mentioned index and bone density of calcaneus by using quantitative ultrasound.Results1. Correlation analysis by spearman showed that there is a significant correlation between age, body mass index, calcium or vitamin D being intaked, the time of menopause, smoking and the bone density, and the coefficient correlation is 0.108-0.322.2. The results of multielement gradually linear regression analysis revealed that age(β=-0.232), body mass index(β=0.105)and sex(β=0.057), COPD(β=-0.884),DM(β=-1.035)were significant relationship of the BMD.3. The results of Logistic regression analysis showed that the important factors that affect bone density include age, body mass index. Increased body mass index can enhance bone mineral density(BMD), aging is risk factors.4. Bone metabolisem, BMD, risk factors and relevance in Type 2 Diabetes Mellitus show that: BMD,BGP were significant decreased compared with control(P<0.05), the level of serum TRACP5b, PTH were significant heighten compared with control(P<0.05). Multiple regression analysis showed that BMI were positively with BMD, the level of serum TRACP5b were negatively with BMD in Type 2 Diabetes Mellitus.5. Bone metabolisem, BMD, risk factors and relevance in chronic obstructive pulmonary disease show that: BMD were significant decreased compared with control(P<0.05), the level of serum TRACP5b, PTH were significant heighten compared with control(P<0.05). Multiple regression analysis showed that BMI and the level of serum 25(OH)D were positively with BMD in chronic obstructive pulmonary disease.Conclusion1. The aged and postmenopaused women,low body mass,with chronic obstructive pulmonary diseases(COPD)and type 2 diabetes mellitus(2DM) are the high-risk people for osteoporosis .2. Bone resorption increased and low bone formation and BMD decrease in old with type 2 diabetes mellitus patients . In elderly patients with COPD, the bone change is characterized by high bone absorption rate and low BMD. Low body mass is a risk factor both above diseases.