| Objective:To observe the combination of Huangqi Danggui Tang mosapride treatment of senile deficiency of qi and blood clinical effects of functional constipation, and from both theoretical and clinical study with mosapride Huangqi Danggui Tang mechanism of action.Method:1. Collection of Hubei Province Chinese Medicine Hospital of Gastroenterology in March 2008-March 2009 aged diagnosed 58 cases of patients with functional constipation according to the order of treatment, using random number table is divided into two groups, treatment group 30 cases in the control group 28 cases. Two groups in age, gender, disease duration, disease no significant difference, with comparable (P> 0.05). Control group was given oral administration of mosapride citrate (trade name:The new network is satisfied, from Chengdu, Southwest Pharmaceutical Co., Ltd. production, the approval document number:National medicine accurate H20031110) 5mg per day 20 minutes before meals three times to take. The treatment group in the control group based on the decoction of Chinese medicine Huangqi Danggui Tang main component drugs Astragalus 20g, Chinese angelica 15g, Atractylodes 15g, hemp seed 12g, habitat 10g, Rehmannia 10g, Cistanche 10g, Fructus 12g, tangerine peel 12g, Bai Mi 15g. Medication Methods:Daily 1, Qu Zhi decoction 600mL, warm clothes in three installments.4 weeks for a course of treatment, a total of two drug treatment. Patients in both groups during the smoking cessation medication temperance, not eating fatty and spicy food, eat food and crude fiber banana, watermelon and other fruits. In addition to the above-mentioned period of not taking drugs other than drugs, closely observe the patient's symptoms, once a week out-patient review and record the changes in clinical symptoms. Respectively, during treatment for safety checks (general physical examination, the three routine examination, electrocardiogram, liver and kidney function tests. Possible adverse reactions) and efficacy of observation. Statistical analysis:Data applications SPSS17.0 statistical software for analysis, using Ridit level data analysis, count data usingχ2 test, measurement data using t test. Results:1. The treatment group 30 cases, clinical recovery in 5 cases, effective in 16 cases, effective in 5 cases,4 cases, the total effective rate 86.67%.Control group,28 cases, clinical cure 1 case, effective 10 cases, effective in 8 cases,9 cases, the total effective rate 67.86%. Efficacy differences between the two groups was statistically significant (P<0.05), an integrated effect of the observation group than the control group.2. TCM after treatment in patients with symptoms of the two groups before treatment compared with the total score differences were statistically significant (P<0.01), the observation group and control group can improve symptoms of traditional Chinese medicine; traditional Chinese medicine in patients with symptoms of the two groups after treatment difference in total score and Statistics significance (P<0.01), observed group total score improved TCM symptoms than the control group.3. The end of treatment were followed up for 6 months to observe the relapse rate was 20.00%, control group, the recurrence rate was 46.43%, the two groups was statistically significant difference in recurrence rate (P<0.05), observe the long-term efficacy than the control group group.Conclusion:The combination of Huangqi Danggui Tang effect of mosapride a comprehensive, long-term outcome is better than western medicine group, the treatment of age-qi and blood deficiency of functional constipation safe and effective herbs, it is worth further study and expand the applications.
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