Zhizhu Xiaopi Decoction Treatment Of Functional Dyspepsia (Liver Stagnation And Spleen Deficiency Syndrome) In Clinical Research

[Objective]The subject to be adopted by clinical comparison of efficacy evaluation of TCM symptoms, adverse reaction rates and relapse rates and other indicators to observe changes in Zhizhu Xiaopi decoction on the efficacy of functional dyspepsia(FD), its scientific and objective assessment of efficacy, and discuss The mechanism of Chinese medicine clinical treatment of functional dyspepsia have positive significance.[Methods]"Chinese medicine clinical guidelines" as the standard, Hubei Province Chinese Medicine Hospital outpatient digested targeting criteria included 58 cases of functional dyspepsia, traditional Chinese medicine for the Liver Stagnation and Spleen Deficiency Syndrome patients were randomly divided into two groups (treatment group, the control group) of the 29 cases, two pairs of sex, age, course of disease, underlying diseases and syndromes, integral aspects of comparison, no statistically significant difference (P> 0.05), comparable. Group was treated with traditional Chinese medicine prescription Zhizhu Xiaopi decoction, a daily one, decoction, a two-clothes, lunch and dinner before the first course of treatment for 4 weeks. The control group I mosapride 5mg, three times a day, take half an hour before meals; omeprazole 20mg, once a day morning course of treatment for 4 weeks. One course of treatment groups were observed and recorded before and after treatment in each group symptoms and symptoms of change, to the statistical analysis, Zhizhu Xiaopi decoction treatment of functional dyspepsia evaluated.[Results]1. Clinical comparison:The treatment group 29 cases, clinical cure in 5 cases, effective in 15 cases, effective in 5 cases,4 cases, the total effective rate 86.21%; control group,29 cases, clinical cure in 3 cases, effective in 11 cases, effective in 5 cases, ineffective in 10 cases, total effective rate was 65.52%.Using X2 test, P<0.05, effect of the treatment group than the control group, with statistical significance.2. Comparison of TCM symptom points:the treatment group compared before and after treatment of the symptom score were significantly difference (P<0.05), the control group, before and after treatment, in addition to loss of appetite, depression or irritability irritability symptom improvement on the two groups had no significant effect (P> 0.05), the rest of the symptoms were significantly improved (P<0.05). The treatment group and control group the symptom score after treatment compared the efficacy of pantothenic acid in addition to belch a considerable (P> 0.05), this distinction with the remaining difference (P<0.05), prompted the majority of the treatment group in improving the clinical symptoms of the various Western medicine is better than the control group.3. Three months after the end of treatment relapse rate comparison: treatment group, three-month recurrence rate was 12.00%, control group, three-month recurrence rate was 31.58%, the two groups were significantly different (P<0.05).4. Comparison of adverse reactions and toxicity:There were no obvious course of treatment, adverse reactions and significant toxicity.[Conclusion]Application of Zhizhu Xiaopi decoction treatment of functional dyspepsia (Liver Stagnation and Spleen Deficiency Syndrome), in improving the cure rate, improving clinical symptoms, relapse prevention, etc. are superior to western medicine control group. From the Chinese medicine theory and Zhizhu Xiaopi decoction to analyze, the party set of square rigorous, starting from the spleen and stomach, conditioning acquired the book, then the four dirty air spleen Kin Wong, and Shugan Jieyu, to treat Liver depression and Spleen-deficiency Syndrome clinical purposes. From the modern pharmacological research and analysis, the side with the promotion of gastric motility, while two-way regulating gastrointestinal role in promoting the secretion of digestive enzymes at the same time nourish the liver and gallbladder, the treatment of indigestion and scientific theory. To sum up to illustrate the Zhizhu Xiaopi decoction on functional dyspepsia (Liver Stagnation and Spleen Deficiency Syndrome) does have a certain effect, it is worth research and extension.