Expression Of Vascular Endothelial Growth Factor In Breast Cancers Tissue And The Relationship With Clinicopathological Parameters

Objective: Breast cancer is one of the most common malignancy of women。The metastasis and recurrence are the key points effecting the quality of life and survival time of breast cancer patients. Based on the determination of vascular endothelial growth factor (VEGF) in 50 cases of breast cancer pathology paraffin blocks, we investigate:①The variability and correlations of VEGF expression in different ages, tumor size, lymph node metastasis, clinical staging of the fifty breast cancer patients.②The correlations of VEGF and estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2(Her-2)expression in the fifty breast cancer patients.③The variability and correlations of VEGF expression in different molecular classification.Methods: Collect 50 cases of paraffin blocks of primary breast cancer specimens who had opretions in the general surgery in our hospital in 2007 for study. These samples all have complete clinical data.Use MaxVision quickly immunohistochemistry to detect the expression in these breast cancer issue, and analysis the immuohistochemistry results by optical microscopy.Then use the chi-square test (χ2) and rank correlation (Spearman) to analysis the relevance of VEGF and various clinical pathological index.Results: In the 50 breast cancers, the positive rate of VEGF is 64%(32/50).The expression of VEGF is significantly positive correlated to the size and the pathogistological type of tumors(r=0.635,0.380,respectively). When lympho node matastasis occurs, the more lymphonodes metastasis, the more VEGF expressed. But the expression of VEGF do not correlated with the ege of the breast cancer patients. ER and PR expression is negative correlated with VEGF expression(r= R=-0.343,0.330,respectively), while the HER-2 expression if positive correlated with VEGF expression(r=0.290). In different types of breast cancers, VEGF expression also differenated, is correlated with the prognosis of different types(P=0.03,r=0.517).Conclusions: VEGF expression is one of the key factors effecting the prognosis of breast cancers, considering its correlations with ER,PR,HER-2, its relative therapies could be used or added into the Conventional treatment of breast cancers, especially used to treat the triple negative breast cancer.