Up-regulation Of Superior Cervical Ganglia Neural-specific10 Protein In The Brain Of Patients With Intractable Epilepsy

Objective To investigate the expression of SCG10(Superior cervical ganglia 10) and MAPK(Mitogen Actived Protein Kinase) in brain tissue of patients with intractable epilepsy so as to explore the possible roles of them in the pathogenesis of intractable epilepsy. Methods The brain tissues of intractable epilepsy patients (n=36) was collected.Expression of SCG10 and MAPK were detected by immunohistochemistry,all results were compared with normal contro1 ,and we investigated the relationship between SCG10 and MAPK by double-label immunofluorescence staining in the IE group. Result The SCG10 staining intensity of immunohistochemistry in the intractable epileptic tissue was (0.4674±0.0258) was significantly higher than those in the control group (0.3405±0.0207,P<0.05),the expresstion of MAPK (0.4217±0.0141) was also higher than those in the control group (0.3189±0.1422 , P<0.05).And by double-label immunofluorescence staining,we investigated the expression of SCG10 and MAPK occurred in the same neuron. Conclusion The results indicate that SCG10 and MAPK overexpression and co-expressionn ,the interaction of them may play an important role in the epileptogenesis of intractable epilepsy.