Research On Assembly System For Microfluidic Chips And Related Techniques

As the development front of biochip, microfluidic chip is one of the important aspects of μ-TAS (Miniaturized Total Analysis System). It has good characteristics, such as high speed, high efficiency, low reagent consumption etc. It has wide application prospects in the fields of biology, high flux medicine formatting and screening, medical diagnosis etc. Miniature function device and interface device are applied to microfluidic chip, which has accelerated the process that the microfluidic chip realizes industrialization and commercializes. Automatic micro assembly system is a key equipment, which realizes that the miniature function device and interface device are assembled.The development, current research situation and problem are summarized. Assembly device and problem while assembling microfluidic chip are studied. The following is the main contents:1. Micro assembly system is designed with "from top to bottom". Besides the three-dimensional workbench, microscope and micro gripper, system has included automatic dispenser of glue and UV spot light source, which is used in glue assembly of microfluidic chip. According to the character of micro assembly, systems software adopts module and OOD philosophy. The high accurate control of three-dimensional workbench and dispenser is realized.2. The character of microfluidic chip and capillary is analyzed, and UV-Curing technology is expounded. A series of experiments have been done, such as "Axle jack", UV-light exposure and glue. Technological parameters have been confirmed, such as injection time, UV-light time etc. And how UV-light time and intensity impact on chip polymer material (PMMA) has been studied too.3. Research on the problems that adhesives may penetrate into the capillary due to the capillary force is carried out. The method of increasing the viscosity of adhesives has been used to solve this problem, which has been proved to be feasible in experiments.4. Aiming at problems that high-accuracy displacement and pressure control is influenced with nonlinear friction, pulse control is presented in this paper. Adetailed study of displacement and press force caused by different torque pulse shapes is presented for device. The models of relation between pulse shape and displacement and relation between pulse shape and press are based.