Professor Wang Yaoxian 's Experience In Treating IgA Nephropathy Based On Data Mining

Objective:To summarize the treatment based on syndrome differentiation and the therapy of professor Wang in treating immunoglohin A nephropathy.Methods:Collecting 70 outpatient who have been diagnosed IgA nephropathy from clinique. To record and file general situation, symptoms, signs, physical and chemical examinations, diagnosis, TCM syndromes, prescriptions and specific drugs of each patient. Using Access to establish electronic database and using Excel to collate data than descriptiving statistics and correlation analysis of data by Weka3.7.5.Results:1.Through descriptive statistics, the main TCM symptoms of the disease were: fatigued spirit and lack of strength 137(81.07%), puffy face and swollen limbs 117(69.23%), soreness and weakness of waist and knees 106(62.72%), dry mouth and throat 94(55.62%), lumbago 86(50.89%), insomnia 77(45.56%), dim complexion 69(40.83%), dizziness and tinnitus 65(38.46%), subject to colds 65(38.46%), eye dryness 58(34.32%), night sweat 57(33.73%), palpitation and shortness of breath 57(33.73%), red and sore throat 54(31.95%).The descriptive analysis of tongue and pulse of each patient, dark 106(49.72%) was the most common tongue color. Greasy fur 127(75.15%) was the most common tongue fur. String and thin pulse 48(28.40%), heavy and string pulse 42(24.85%), heavy and thin pulse 42(24.85%) were the most common pulse. The main syndrome elements were:qi-deficiency 119(70.41%), yin-deficiency 111(65.68%), yang-deficiency 26(15.38%), blood stasis 132(78.11%), damp heat 71(42.01%), wind-heat 45(26.63%), qi stagnation 70(41.42%), phlegm-dampness 19(11.24%). The main syndromes of this disease were:qi and yin deficiency 69(40.83%), spleen and kidney qi deficiency 50(29.59%), liver and kidney yin deficiency 40(23.67%), spleen and kidney yang defuciency 10(5.91%), blood stasis 132(78.11%), damp heat 81(47.93%), qi stagnation 70(41.42%), wind heat 50(29.59%), phlegm dampness 19(11.24%). the most common used four types of Traditional Chinese Medicine were:tonic drugs 701(25.98%), heat-clearing drugs 371(13.75%), stasis eliminating drugs 299(11.12%), damp-inhibiting drugs 227(8.44%), qi-tonifying drugs 231(32.95%), yin-tonifying drugs 203(28.96%)were the most used tonic drugs. The top ten drugs in accordance with frequency were:NiuXi 120(63.83%), MuLi 99(52.66%), BaiShao 94(50.00%), HuangQi 92(48.94%), FuLing 89(47.34%), SanQi 87(46.28%), HaiZao 86(45.74%), YiYiRen 72(38.30%), ChaiHu 63(33.51%), SuanZaoRen 61(32.45%).2.Data association analysis based on "support-confidence" were:①Drugs closely related to qi deficiency:HuangQi with a confidence of 91.30% and BaiZhu with a confidence of 80.00%. Drugs closely related to yin deficiency: ShengDi, ShiHu, MaiDong, HanLianCao, NvZhenZi with confidence of 100.00%,100.00%, 100.00%,96.30%,95.00% respectively. Drugs closely related to blood stasis:HongHua, ChuanXiong, DiLong, HaiZao, BieJia, DangGui, TaoRen, MuLi with confidence of 100.00%, 100.00%,97.67%,96.97%,96.23%,96.00%,95.92% respectively. Drugs closely related to damp heat:Cangzhu and YiYiRen, with confidence of 95.65% and 76.39% repectively. Drugs closely related to qi stagnation:ZhiQiao and ChaiHu, with confidence of 80.39% and 69.84% repectively. Drugs closely related to wind-heat:ChanTui, JingJie, JinYinHua, QingFengTeng, with confidence of 100.00%,100.00%,60.00%,56.25% repectively.②HuangQi is closely related to fatigued spirit and lack of strength, puffy face and swollen limbs, soreness and weakness of waist and knees, palpitation and shortness of breath and lumbago, the confidence were 98.11%,71.74%,75.00%,44.57%,53.26%. ③The confidence of BieJia and MuLi, BieJia and HaiZao were 93.94%,90.91%. The confidence of DangGui and MuLi, DangGui and HaiZao were 77.36%,75.47%. The confidence of HaiZao and MuLi, HaiZao and HuangQi were95.35%,76.74%. The confidence of LongGu and MuLi, MuLi and HaiZao, MuLi and HuangQi were 100.00%,83.67%,71.43%. The confidence of HuangQi and MuLi, HuangQi and HaiZao were76.09%,71.74%. The confidence of ShengDi and HuangQi were 82.93%. The confidence of CangZhu and YiYiRen, YiYiRen and NiuXi, HuangBai and CangZhu, HuangBai and YiYiRen, were 95.65%,77.78%,100.00%,100.00%. ④Multiple associations between drugs:HuangQi, DangGui, ShengDi, HaiZao, MuLi, DaHuang co-occur 11 times, HuangQi, DangGui, HaiZao, MuLi co-occur 28 times, HuangQi, ShengDi, HaiZao, MuLi co-occur 26 times. CangZhu, HuangBai, YiYiRen, NiuXi co-occur 16 times. ChaiHu, ZhiQiao, BaiShao co-occur 34 times. GouJi, XuDuan, NiuXi, BaiShao co-occur 16 times.⑤The confidence of damp heat and CangZhu, HuangBai, YiYiRen, NiuXi were 100.00%. The confidence of blood stasis and HuangQi, DangGui, ShengDi, HaiZao, MuLi, DaHuang were 100.00%. The confidence of qi deficiency and HuangQi, DangGui, ShengDi, HaiZao, MuLi, DaHuang were 100.00%. The confidence of yin deficiency and HuangQi, DangGui, ShengDi, HaiZao, MuLi, DaHuang were 100.00%.⑥fatigued spirit and lack of strength, puffy face and swollen limbs, dry mouth and throat, dim complexion, dizziness and tinnitus were all closely related with HuangQi, DangGui, ShengDi, HaiZao, MuLi, DaHuang, the confidence were 81.82%,72.73%,100.00%,54.55%, 90.91%,63.64%,90.91% respectively. Soreness and weakness of waist and knees, lumbago were both closely related with GouJi, XuDuan, NiuXi, BaiShao the confidence were 100.00%, 100.00%,75.00% respectively.Conclusion:1.The main TCM symptoms of the disease were:fatigued spirit and lack of strength, puffy face and swollen limbs, soreness and weakness of waist and knees, dry mouth and throat, lumbago, insomnia, dim complexion, dizziness and tinnitus, subject to colds etc. 2.dark is the most common tongue color, greasy fur is the most common tongue fur, String and thin pulse is the most common pulse.3. The main syndrome elements were:qi-deficiency, yin-deficiency, yang-deficiency, blood stasis, damp heat, wind-heat, qi stagnation, phlegm-dampness.4.Among all the causes of diseases, the invasion of pathogenic factor is considered the original cause of diseases, and weakened body resistance comes second. With the development of a disease, the combined symptom of deficiency and excess comes into being as a result of the change from excess to deficiency. If the condition does not improve for a long time, prolonged illness can enter into venation, eventually result in "micro lump in kidney venation".5.CangZhu, HuangBai, YiYiRen, NiuXi; HuangQi, DangGui, ShengDi, HaiZao, MuLi, DaHuang; GouJi, XuDuan, NiuXi, BaiShao are commonly used as combination.6. Individual treatment is recommended.