| Objective:Observe the progress in the process of TCM syndrome characteristics and objective index change; To explore TCM syndrome with anthropometry and test index of correlation.Methods:165 MS patients(2010 CDS diagnosis standard,but non-DM) from march 2014 to december 2015 in 14 research units and the Beijing dongcheng district of Beijing community health service centers.The data of demogrsphic data(including name, gender, age, date of birth, nationality, personal history, family history, past medical history, history of allergies, diet, exercise, drug taking), human body measure (including weight, height,weight,BMI Waistline,hipline,W/H ratio), physical examination (including breathing, heart rate, body temperature, SBP,DBP) are descriptive statistically analyzed. And the baseline, follow-up of 6 months and follow-up of 12 months,these three groups of traditional Chinese medicine syndrome and test index (including FBG,HbAlc,TC,TQHDL-C,LDL-C,ALB,Scr,UA) are compared, which are in order to observe the changes of them. And the binary logistic regression analysis is applied to find the correlation butween TCM syndrome and the parameters or indexes such as BMI, W/H ratio, SBP, DBP, FBG, HbAlc, TC, TG, HDL-C,LDL-C,ALB,Scr,UA, which are in order to find out the indicative parameters or indexes.Moreover, according to patients for 12 months without progression to diabetes, MS patients are divided into progressed group and non-progressed group, compared two groups of TCM syndrome type and test index differences, find out with MS patients progress for the main syndrome types and risk factors of DM patients, so as to guide the clinical prevention and treatment.Resultsr①Demographic data:The 165 MS patients ages from 50 to 69 while the average age is 62.The ratio of man to female is 1:2.②As to the components of MS,107 patients(64.8%) have hyperlipidemia.120 patients(72.7%) have hypertension.59 patients (35.8%) have diabetes,133 patients(80.6%) are overweight.31 patients(18.8%)have the high uric acid.30 patients(8.2%) have coronary heart disease. ③The baseline distribution of syndromes:116 cases of kidney deficiency, accounted for 70.3%; Belong to Yin deficiency,103 cases (62.4%); Is a hot and humid,88 cases (53.3%); 85 cases of kidney Yang deficiency, accounting for 51.5%; Liver Yin deficiency,79 cases (47.9%); Belongs to qi deficiency,78 cases (47.3%); Kidney Yin deficiency,73 cases (44.2%); Belongs to the work,55 cases (33.3%); Belong to blood stasis,45 cases (27.3%); Yang,43 cases (26.1%); Phlegm turbidity,40 cases (24.2%); 37 cases of liver blood deficiency, accounting for 22.4%; And qi stagnation,34 cases (20.6%); Blood deficiency,33 cases (20.0%); Hotness,16 cases (9.7%); Lung qi deficiency,13 cases (7.9%); Spleen-deficiency,11 cases (6.7%); Belongs to the spleen Yang deficiency,11 cases (6.7%); Is water wet,1 cases (0.6%).④The correlation butween TCM syndrome and the parameters or indexes:Heat is positively correlated with BMI, and W/H thewire, negatively correlated with SBP, HDL-C; The spleen Yang deficiency was positively correlated with TG, LDL-C, and negatively correlated with the TC; Temper was positively correlated with TG, Scr, and negatively correlated with UA. Positive correlation between FBG and liver blood deficiency, and negatively correlated with HbAlc;Lung qi deficiency was positively correlated with W/H thewire; Phlegmy wet and W/H thewire were positively correlated; Virtual effort and LDL-C were positively correlated,the difference was statistically significant.BThe transformation of TCM syndromes from Baseline,follow-up of 6 months and follow-up of 12 months:Qi deficiency, blood deficiency, Yin deficiency type, kidney Yin deficiency type and heat type phase from baseline to follow-up of 12 months has been a declining trend.Spleen-deficiency type, blood deficiency, liver blood deficiency, spleen Yang deficiency, and qi stagnation and phlegm turbidity type from baseline to follow-up of 12 months has been a rising trend.The other of else has fluctuations.⑥The transformation of test indicators from Baseline,follow-up of 6 months and follow-up of 12 months:The difference of ALB between Baseline and follow-up of 6 months was statistically significant,MS patients’ALB of follow-up of 6 months are inferior to the Baselines.The difference of HbAlc,LDL-C and ALB between follow-up of 6 months and follow-up of 12 months was statistically significant.MS patients’HbAlc and ALB of follow-up of 12 months above the follow-up of 6 months.MS patients’LDL-C of follow-up of 12 months are inferior to the follow-up of 6 months.The FBG, HbAlc and Scr of followed up for 12 months and the difference was statistically significant between the baseline results, namely MS patients were followed up for 12 month of HbAlc and FBG is higher than the baseline, MS patients were followed up for 12 month is lower than the baseline levels of Scr.⑦Lung qi deficiency, spleen Yang deficiency, and heat is associated with MS progress for DM. Lung qi deficiency is the risk of diabetes is 6.81 times that of pulmonary qi deficiency patients of spleen Yang deficiency is the risk of diabetes is 4.06 times of the spleen Yang deficiency, hotness is the risk of diabetes is 3.31 times of hotness. Glycated hemoglobin and fasting glucose levels of the progressed group are higher than in the non-progressed group group, and the differences were statistically significant (P< 0.001). Conclusion:80.6% of 165 MS patients are overweight,which should be taken into consideration seriously. MS patients in TCM syndrome factor:deficiency syndrome is given priority to with kidney deficiency, Yin deficiency, kidney Yang deficiency; Demonstration is given priority to with hot and humid.The research proves that BMI,W/H ratio,SBP,FBG, HbAlc,TC,TQHDL-C,LDL-C,ALB,Scr and UA are correlated with The TCM syndromes, HbAlc,FBG,ALB and Scr are closely associated with MS progress for DM, and MS progress for DM related TCM syndrome types for lung qi deficiency, spleen Yang deficiency and heat; Glycated hemoglobin and fasting plasma glucose is MS to the risk factors of DM,which can guide the clinical treatment. |
PDF Full Text Request