Investigation Of Fabricating Microneedles For Blood Sugar Monitoring Microsystem

Sugar diabetes is one of diseases inperiling the human healthes in the morden society. It's important to steady the blood sugar for the diabetics that monitoring the concentration of blood sugar in evey time, and transporting the medicament like insulin into the body in time. To this monitoring and controling system, how to allevaite the patients' pains when they're facing the blood sugar measure and the insulin transportant, is the key to set up the microsystem. And the key part to solve this problem is microneedle. Microneedle is an acicular structure usually made through microfabrication process, of which the diameter is around 30 to 80μrn and the length is above 100μm. The material of microneedles could be silicon, polymer, metal and etc. Microneedles have a comprehensive application for the biomedicine field, such as the biomedicine measure system, drug delivery system, microanalysis system and etc. Microneedle not only has tiny volume, but also has several characteristics, which the convention methods may not have, for example exactness, painless, high efficiency and convenience.Chapter I introduced the basic conceptions, fabrication technologies and the new developments of MEMS have been at the first part. And then the properties, basic theories and developing process of microneedle fabrication have been introduced through comparing it with other fabricating technologies. The main diploma work was briefly introduced.In chapter II, basing on the microneedles fabricating process flow, the principles of every microfabrication process which were used in the flow, include sputter, microlithography, oxidation and etching, were introduced. A computer control system was developed for the control of the electroplating process. The software environment is Labview. At last some issues met in the process flow were analyzed.The influence of technological parameters to the electroplating process is studied in Chapter III. Where, the concentration of the elements of electroplating solution, including Ni(SO₃·NH₂)₂, H₃BO₃, NiCl₂, lauryl sulfate, glucide and etc. PH. temperature and current density have been explored to the electroplating qualities.A finite element method program was used to simulate the stress caused by the change of circumstance temperature in chapter IV. From the result it's directly prove the opinion the silicon molds can be cycled reused. And then the force caused by the microneedles piercing human skin was simulated, and the results prove that these microneedls can be strong enough to burden the force to pierce human skin. Finally.