Chemical Constituents Of Cryptocarya Concinna

This thesis reports the structure and bioactivity of secondary metabolites produced by the plant Cryptocarya concinna Hance. Forty-four compounds were isolated from the 95% EtOH extract by chromatographic methods, including silica gel, Sephadex, ODS, TLC, and semipreparative HPLC. Comprehensive spectroscopic data interpretation of UV, IR, LC-MS, NMR, CD and X-ray crystal analysis were used to determine the structures of the compounds. The cytotoxic and antimicrobial activities of some compounds were also evaluated.Twelve new flavonoids, cryptoconones A-L (1-12), along with thirty-two known compounds (13-44), were isolated from the stems of Cryptocarya concinna. Compounds 17 and 25 exhibited moderate cytotoxic activities against HCT116, HT29, SW480 and MDA-MB-231 cell lines with IC50 values ranging from 6.25 to 9.35μM. Compounds 8-11 showed weak antifungal activity against Alternaria solani, with the same MIC of 40μg/mL. Compounds 15 and 26 exhibited significant antimicrobial activity against Fusarium moniliforme and Botrytis cinerea respectively, with the same MIC of 5μg/mL.Moreover, researches on the genus Cryptocarya since the 1960s were reviewed in this dissertation.