Study On Preperation Of MNPs By Solvent And Microemulsion Method And Its Rare Earth Doped Properties

nanoparticles are non-toxic and biocompatible, and have good chemical stability. It’s widely used in biomedical application, such as magnetic separation/labeling of cells, contrasting agent in magnetic resonance imaging, localizer in therapeutic hyperthermia and magnetic targeted-drug delivery system, localizer in therapeutic hyperthermia, etc. Fe3O4particles with high saturation magnetization are synthesized by solvent method and microemulsion method. Rare earth doped Fe3O4particles and Fe3O4@SiO2composite are synthesized in water-in-oil microemulsion, and corresponding amino-coated magnetite nanoparticles are also obtained via surface modification.Firstly, size adjusted Fe3O4particles are prepared using Fe(acac)3as iron source, ethylene glycol, ethanol, isopropyl alcohol as solvent. The influence of different solvents conditions on morphology and properties of Fe3O4particles were discussed. Targeted rejection experiment was done to Fe3O4nanoparticles.Secondly, Fe3O4was synthesized in a water-in-oil microemulsion, using polyoxyethylene (15) cetylether as surfactant, FeCl2·4H2O and FeCl3·6H2O as iron source, NH3-H2O as precipitant. The reacting factors, such as NH3H2O concentration, the molar ratio of water to surfactant, iron mole ratio, reacting temperature and reacting time were studied. Targeted rejection experiment was done to Fe3O4nanoparticles.Thirdly, based on the water-in-oil microemulsion reaction, Fe3O4particles doping with rare earth ion(Eu3+、Dy3+)are synthesized, the morphology and properties of production are characterized and discussed.Finally, based on the water-in-oil microemulsion reaction, well dispersed Fe3O4@SiO2composite was prepared, using TEOS as silica resource and NH3·H2O as precipitant. The reacting factors, such as precipitant, the molar ratio of water to surfactant, iron salt concentration, TEOS concentration and reacting time were studied. And amino modified Fe3O4@SiO2composite with abundant NH2was prepared, which is favarable to further study of target drug.