Preparation Of Graphene Oxide Modified Polysebacic Anhydride And Polycaprolactone And The Study Of Controlled Delivery System

Polyanhydrides have been considered to be useful biodegradable polymers, which have good biocompatibility, surface-eroding behavior and the adjustable degradation rate. At the same time, polycaprolactone has the properties of unique biocompatibility, biodegradability and good permeability. So they are potential for biomedical applications and good drug carrier materials. In this thesis, poly(sebacic anhydride) and polycaprolactone are modified by graphene oxide to overcome the deficiency of poly(sebacic anhydride) and polycaprolactone as a carrier material. Thus we obtained high quality drug carrier materials which are more suitable for clinical use.Firstly, graphite oxide was prepared by Hummers method, and then was subjected to ultrasonic treatment in distilled water to prepare graphene oxide. Graphene oxide was characterized by means of IR, XRD and DSC. The analysis results show that graphene oxide was successfully prepared and there were a lot of oxygen functional groups, such as hydroxyl, carboxyl, carbonyl, epoxy group, etc.Secondly, poly(sebacic anhydride) was synthesized by melt condensation and polycaprolactone was prepared by the ring-opening polymerization.The polymers were characterized by IR,XRD and DSC.Thirdly, Graphene oxide modified poly(sebacic anhydride) composites (GO/PSA) and polycaprolactone composites (GO/PCL) were synthesized by Steglich esterification and characterized by IR, XRD, DSC and GPC. The analysis results show that GO/PSA and GO/PCL were successfully prepared.Finally, lomefloxacin hydrochloride(LMF) was chosen as the model drug, GO/PSA and GO/PCL were used as drug carrier material for preparing tablets. And the drug sustained release properties were preliminarily studied.The sustained release experimental results show that GO/PSA and GO/PCL can effectively adjust the drug release time and release the drug at a constant rate, reached the controlled release requirements. Different additive amount of graphene oxide has different effect on adjusting sustained release time.4%GO/PSA and4%GO/PCL as carrier of drug showed the best results. Exploring the optimum additive amount of graphene oxide is very significant for the future development of GO/PSA and GO/PCL carrier material.