Preparation Of Fluorescent-magnetic Multifunctional Nanocomposite And Its Application In Anti-cancer Drug Delivery

Design and assembly of multifunctional nanocomposite and its applications in the diagnosis andtreatment of cancer are research focus of the interdisciplinarity field of biology, chemistry, materialand medicine. Multifunctional nanocomposite is referred to as "multifunctional features", because itcan combine or encapsulate a variety of chemical compositions, including tumor targeting molecules,fluorescent dye molecules and more functional elements such as anti-cancer drug molecules，torealize the single function diversified, and to simultaneously come true fluorescence imagingdetection, controlled drugs delivery and cancer treatment. At the same time, multifunctionalorganic-inorganic nanocomposite carrier is in the rapid development of all kinds of stimulus responseand their synergy, especially the synthesis of multifunctional and stimulus responsive nanocompositematerials and their application in biomedical research have attracted more and more interests.In this paper, multifunctional eccentric core-shell structure composite (Fe3O4@fmSiO2)@PAAwith fluorescent-magnetic and pH stimulus response was controllablly prepared, of which Fe3O4nanoparticle coated by fluorescent mSiO2as a nuclear, eccentric structure of PAA as a shell.Compared with the preparation of traditional pH responsive polymer, this method is simple, and thereaction is carried out at room temperature. This novel eccentric multifunctional nanocomposite notonly possesses the pH stimulus responsive drug release property, but also has high drug loading, so itcan be used for the integration research of fluorescence imaging in the diagnosis of prostate cancercells and pH stimulus response of controlled drug release. At the same time, the eccentric structureFe3O4@PAA was synthesized, and then gold nanoclusters (Au NCs) and anti-cancer drug DOX wereloaded into the PAA shell. Because of the pH stimulus response of the zeolite imidazoles skeletonstructure materials (ZIF-8), ZIF-8was covered around the PAA layer of the Fe3O4@PAA, tofabricate multifunctional eccentric core-shell structure composite (Fe3O4@PAA-Au NCs)@ZIF-8with fluorescent-magnetic and pH stimulus response property. As drug carrier, the multifunctionalnanocomposite possesses high drug loading and the property of pH stimulus response of controlleddrug release, which has the potential biomedical application.