| In recent years, the massive application of synthetic polymer materials based onpetroleum resources have not only caused increasingly serious pollution problems, butexacerbated the threat of depletion of oil resources. With the urgent requirement forconstituting resource saving and environment friendly society, more and moreresearchers have been concentrated on the renewable resources from natural animal andplant which will likely become the next major chemical raw polymeric materials in thefuture. Feather keratin materials have potential application prospects as its rich source,low price, renewability and biodegradability characteristics. Considering the poormechanical properties of FK film, films were fabricated by blending FK and sodiumcarboxy methyl cellulose. And their properties were investigated to ensure that thesefilms could be applied in packaging, agricultural film materials and drug release fields.Blending feather keratin and sodium carboxy methyl cellulose, compatibilized byglycerine, complex films were prepared by solution casting. Infrared spectrum(FT-IR),X-ray diffraction(XRD), scanning electron microscopy(SEM), differential scanningcalorimetry(DSC) and ultraviolet(UV) were used to study the structure and consistencyof the blending films, and the different content of CMC and glycerine on themechanical, thermal stability, water-solubility and permeability properties. FTIRanalysis showed that Maillard reaction occurred between FK with CMC; SEM resultsshowed that FK/CMC blend films had a flat surface and a dense internal structure; DSC,XRD and UV transmittance results showed that FK had well compatibility with CMC.Tensile tests indicated that the content of CMC and glycerine had a significant effecton the mechanical properties of blend films. CMC enhanced the tensile strength of thefilm, and glycerine can effectively improve the toughness of the blend films； TGAresults showed that CMC enhanced the thermal stability of the blend films. And theresults of water solubility also indicated that a different degree of swelling in theprocess of dissolution was obsevered, and the dissolution rate of the films increaseswith increasing temperature; the results of contact angle test showed that the contactangle values of blend films were less than90°, indicating the hydrophilicity, and it worsens as increased glycerol content; The results of the moisture permeability showedthat the amount of water vapor through the film in the range of values between932.37and2298.51(g/m224h), and the values increased with the increasing of the CMC andglycerol content.On the basis of FK/CMC film prepared, studies on the application in the drug areawere carried out. FK/CMC films cross-linked by citric acid were prepared for in situcontaining rhodamine model drug. FK and CMC films can form network structures ascitric acid added more than0.2wt%. SEM showed that FK/CMC films crosslinked bycitric acid became more impact; the addition of citric acid improved the degree ofcrosslinking of the FK/CMC films, reducing the rate of dissolution in water andenhancing the tensile strength of the FK/CMC films. Rhodamine drug release curvefitting demonstrated the diffusion characteristic index0.5<n<1of citric acidcrosslinking FK/CMC films, and thus the release of such drug can be judged as Case IIItransmission mode, which coexist with the carrier dissolution.In short, keratin extracted from discarded feathers was used as a raw material forpreparation of FK/CMC blend films, not only making full use of the renewable proteinresource, but conforming to current environmental requirements. FK as a matrix ofdrug carrier material is expected as a novel drug carrier material used in thepharmaceutical field. |
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