Syntheses, Structures And Properties Of Aromatic Carboxylate Complexes

In recent years, supramolecular complexes constructed by carboxylic acidsthrough both covalent bond and weak interactions have attracted great interest ofchemists. Aromatic carboxylate and their derivatives have attractive properties due totheir functional structures. Especially, they have been applied in many fields such asanalytical chemistry、nonlinear-optical materials and catalytic materials. Particularlytransition metal complexes have a wide range of biological applications for theirmany kinds of pharmacological activities, much attention has also been devoted tothem. And people consider transition metal complexes one of the topical issues all thetime. In this thesis, a series of complexes based on aromatic multicarboxylic acidshave been successfully synthesized in solutions or under hydrothermal conditions.Their structure and properties are investigated.(1) Eight complex compounds have been synthesized and characterized byX-ray single crystal diffractive technology: The eight complexes are listed asfollowing:[Cu2(BzO)4(EtOH)2] complex1[Cd2(cdm)2(H2O)4]·4H2O complex2[Co(H2btc)(phen)(H2O)3] complex3[Co2(btc)(phen)(H2O)2]·H2O complex4[Ni2(btc)(phen)2(H2O)4] complex5[Cu2(btc)(phen)2(H2O)4] complex6[Co(H2biim)2(H2O)2](H2btc) complex7[Zn(H2biim)2(H2O)2](H2btc) complex8The structure of complex1is dinuclear complex resulted from weakinteractions（0-D chain）; complex2is1-D chain stucture result from interactions ofwater molecules; complex3、4、5、6are coordination polymers using hydrothermalsynthses, where the first kind ligand is H4btc, the second kind ligand is phen andCo2+、Ni2+、Cu2+as center ions, respectively. While the coordination enviroment ofCo2+is the same in complex3, the coordination geometries around the Co atoms incomplex4are obviously different because of the different reaction conditions. Incomplex4, the1-D chains are connected into2-D layer through carboxy groups of ligand H4btc. The structures of complex5、6are1-D chain stucture result frominteractions of carboxy groups in ligand H4btc. Complex7、8are homeomorphycompounds. Either of them are linked to the3-D chains through intermolecularhydrogen bonds. Each H4btc lose two protons and H2btc2-acts as negative electronbalance.(2) The ligands and complexes have been characterized by IR, Furthermore theIR have been employed to characterized the above compounds. Then fluorimetricanalysis has been used to study complexes2、8and their ligands.(3) The electric-chemistry behavior of complex1has been characterized.(4) We investigated the anticancer activities of complex1in vivo by usingTrypan blue dye exclusion method. The complex1inhibited the proliferation ofK562cells(chronic myeloid leukemic cells) significantly and dose-dependently in48h, IC50of K562was17.3μg/mL by trypan blue dye exclusion method. Theinhibitory effects of complex1to staphylococcus bacteria、bacillus pyocyaneus、bacillus levans、bacillus coli and citric acid bacili were characterized in experiment.The result of MIC shows that complex1inhibited those bacteria significantly.