Two Optical Chemosensors For Copper Ion And Viscosity

With the rapid development of various sciences (especially the biological science), it is of great significance to detect accurately and rapidly. Fluorescent probe is an excellent kind of biomolecular sensors which is widely used due to its high selectivity, high sensitivity, easy of operation, in situ and real-time detection.Copper is an essential transition metal elements and play a vital role in environmental, chemical, and biological systems. It exists in the natural water cycle system of various forms, but cupric ions are considered to be toxic for the aquatic environment. Cu2+ions could enrich to human body through food chain and harm to human health seriously. Therefore, it still has a very important significance to quickly detect Cu2+ions in the environment. We designed and synthesized a rhodamine-based probe RCu, it can specific identification of copper ions in aqueous solution without interference by other ions. The limit of detection of RCu is very low that the color of solution can be changed in the presence of1uM Cu2+ions, allow the naked eye colorimetric detection of Cu2+ions in aqueous solution. Furthermore, It can be made into test paper for rapid detection of Cu2+ions in the environment in the ppm level.Viscosity greatly influences the interaction between biomolecules, the transportation of chemical signals and mass, and the diffusion of reactive metabolites in living cells, such as RNS and ROS. Different regions have different viscosity. If the viscosity changes abnormally, it could cause a wide range of diseases. So quantifying the viscosity in living cells has a great significance. Herein, we synthesized a hemicyanine derivative C1, which showed a nice response to viscosity, C1is not interferenced by solvent polarity. And it fits the Forster-Hoffmann equation and could image viscosity in living cells.