Novel And Efficient Synthesis Of Dhpms Catalyzed By DI-DACH-Pyridylamide Ligands And One-Pot Synthesis Of Indoles Derivatives

This dissertation consisted of two parts:The first part was novel and efficient synthesis of DHPMs catalyzed by di-DACH-pyridylamide ligands. Moreover, based on the optimized condition, a novel Biginelli-like reaction of2,2’-(butane-1,4-diylbis(oxy))dibenzaldehyde, urea and ethylacetoacetate was first developed. The second part was one-pot, synthesis of indoles derivatives in the water. And this study was satisfied with the requirement of green chemistry.Part1:Multifunctionalized3,4-dihydropyrimidin-2(1H)-one deriv-atives (DHPMs) were very important pharmacologically active molecules Di-DACH-pyridylamide ligands and symmetrical bridged bis-Schiff base as catalysts in the synthesis of DHPMs using the Biginelli reaction is first reported. And a series of dihydropyrimidinethiones (DHPMs) were obtained in high yields (78%to98%). Moreover, based on the optimized condition, a novel Biginelli-like reaction of2,2’-(butane-l,4-diylbis(oxy)) dibenzaldehyde, urea and ethylacetoacetate was first developed and the yield was78%.Part2:Coumarin is not only a kind of important spices, but also have a variety of biological activity. This study investigated a high-efficient green approach to indoles derivatives performed by reacting isatins and coumarin as starting materials in water. This new protocol has the advantages of environmental friendliness, wide applicability, lowcost catalyst (HC1), short reaction time (only10min) and excellent yields (99%).