| Chemical probes play an important role in the fields of analytical chemistry, biology and environmental sciences. The fluorescent probes are both sensitive and selective. And they are also rapid, easily carried out in real time and space. Organic small-molecule fluorescent probes are easy to be designed and prepared, and attract special attention. Therefore, reaction-based fluorescent probes are developing through various approaches with different theory and design strategies.Sulfite is widely used as the additive for foods and beverages to preserve their freshness and shelf life. However, sulfite in high doses can cause asthmatic attacks and allergic reactions in some individuals. The sulfite content in foodstuffs is strictly limited in many countries. Therefore, it is critical important to realize rapid, cost-effective, sensitive and selective detection of sulfite. Utilizing pyrene group as fluorophore, we designed a novel sulfite reaction-based ratiometric fluorescent probe (PP-1) which based on ICT process. In ethanol and water solvent system, sulfite reacted with PP-1by Michael addition reaction. The UV absorption and fluorescence emission were greatly changed. This probe achieved high selectivity and the color changes were easily observed by naked eyes.Copper is an essential trace element responsible for the function of many cellular enzymes and proteins. Disruption of copper metabolism or its uptake will result in serious health problems such as Wilson’s, Menkes and Parkinson’s diseases. Numerous fluorescent sensors for Cu2+ions have been described, but reaction-based probes based on ESIPT process are rare as far as we know. We designed and synthesized a Cu2+probe (HBO-EP) based on2-picolinate ester. In acetonitrile/water solvent system, the2-piolinate ester was hydrolyzed by Cu2+complexing reaction and the fluorescence intensity was enhanced. This novel probe has high sensitivity and excellent selectivity for Cu2+ions over competing metal ions. |
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