Synthesis Process Of Losartan

Iosartan chemical name is 2-butyl -4-chloro -5-(hydroxymethyl)-1-[2’-(1H-tetrazole-5-) biphenyl-4-]]methyl imidazole,which was jointly developed by Dupont Merck Pharmaceutical Company and the Merck Company,listed the first non-peptide angiotensinⅡreceptor antagonist.In this paper,2-butyl4(5)-chloroimidazole-5(4)-carboxaldehyd and 4-bromomethyl -2 -cyano group biphenyls,respectively were prepared from pentanitrile via thre-step process and O-chlorobenzonitrile.The intermedia was prepard through the condensation,reduction,and then reacted with azides to form tetrazole.Intermediates and the target product of the chemical structure characterized by infrared spectroscopy,nuclear magnetic resonance NMR,mass spectrometry and elemental analysis and the main factors affect the reaction was discussed, which compared losartan to be a better network synthesis reaction conditions.This paper aims to explore a new,more suitable for industrial synthesis route in order to improve the synthesis of the regional selectivity.These series of compounds in industrial production will be more easier to control,and lay a good foundation for create the conditions for the development of new drugs.