.plga / Tio <sub> 2 </ Sub> Nano-drug Delivery Carriers

In order to get high bioactive and good drug delivery carrier, novel nano bio-degradable and the organic-inorganic hybrid materials with nano-titanium dioxide. The surface modification process and PLGA was carried further to increase their interface compatibility. In addition, the materials behavior was characterized and analysis. and the hybrid materials biocompatibility and drug delivery carriers were studied(1) In the first step, the y-Aminopropyltriethoxysilane (KH550) was grafted on the surface of titanium dioxide, and then reacted with high activity-terminated poly(lactic-acid-glycolic-acid) (PLGA), prepared the PLGA/TiO2 organic-inorganic hybrid nano-materials. The research results shows that, the PLGA bonded through the amide bond grafted onto the surface of TiO2 nanoparticles in the PLGA/TiO2 organic-inorganic hybrid nano-materials, PLGA grafted amount of 13.2%, and the hybrid material dispersion had a better improve, and no obvious agglomeration.(2) First of all, PLGA was modified into sulfuric acid terminated, and reacted with titanium dioxide sol-gel through the sol-gel technology, perpetrated the PLGA/TiO2(SPLGA/TiO2) organic-inorganic hybrid materials. The Studies results show that, SPLGA/TiO2 organic-inorganic hybrid materials, sulfuric acid terminated PLGA was successful prepared and grafted on the surface of TiO2 nanoparticles through amide. PLGA grafted amount of about 20%, SEM photographs shows that hybrid materials has a good dispersion, no obvious agglomeration. PLGA grafted on TiO2 surface was formatted parcel layer, effectively improved the dispersion of TiO2 and homogeneity, and SPLGA/TiO2 organic-inorganic hybrid materials had excellent biocompatibility which we can see from the cells experiments and suit as a drug carriers in the drug control systems.(3) SPLGA/TiO2 microspheres were prepared by firstly absorbing model drug BSA onto SPLGA/TiO2 nano particles and then coating with PLGA via S/O/W method, compared with nano-TiO2. Using UV-Vis and TEM, the absorbing behaviors of BSA onto nano particles and the impact of preparation method on the drug loading efficiency and in vitro controlled drug release were studied. The results showed that the two kinds microspheres all had a high encapsulation efficiecy, greater than 90%. SPLGA/TiO2 nano particles had a higher BSA adsorption, increased from 43.31% to 81.34%. The SPLGA/TiO2 microspheres had a high drug loading and a smaller burst in vitro behavior.