Nucleophilic Research Of Benzimizole Carbenes And Seleno-isocyanates

Carbenes play an important role in organic chemistry, since it be determined intermediate. In early years, most of carbenes is N-heterocyclic carbene, the reactions about it were limited metal complexes. Until 1991, the first free N-heterocyclic carben was isolated, carbens is not only join metal complexes, but also got a great effect in benzoin reaction, and catalytic in intramolecular asymmetric of stetter reaction.Because reactive of carbends has very high activity of reaction, it showing the status of pharmaceutical intermediates. Benzimidazole and its derivatives can not be neglected in drug intermediate fragments. Circle of benzimidazole structure many medical molecules are always used in antagonists, proton pump inhibitors, antihypertensive, antiparasitic, antibacterial, antifungal, anticancer and antiviral agents. It also be used in metal corrosion, high performance composites and dye. In this thesis, we have reviewed the recent advance in the studies on the structures, synthetic, applications and biological activity, use of its nucleophilic, take different substituent'selenium with isocyanate in reaction, synthesis 5 dipoles, and reactive with DMAD, reacted 5 spiro compounds,take condition experiment with base, solvent and temperature.This thesis is divided into four chapters. In the first chapter, introduction the structure, synthetic, application and biological activity of carbenes, benzimidazole compounds, isocyanate compounds, thiazole compounds and tetrazine compounds. The second chapter is talk about the mean of this project and why to do this, the third and fourth chapter is the part of experimental, content include three parts, one part is reaction of 1,3-2 benzyl benzimidazole with bromobenzene seleno-isocyanate, react 1,3-2-benzyl-2(seleno-amidebromophenyl)-benzimidazole dipole, then it reactive with DMAD, got product 1,3-2-benzyl-2-(2-bromoimide-4,5-diendimethyl-3-Se-Ering) benzi -midazole, and optimum reaction conditions. Another part is change the substituent of benzimizole carbine and selenium with isocyanate, and determine them structures through IR, 1HNRM, 13CNMR, MS. Latest part is a experimental exploration of thiazole and tetrazine.