Palladium-catalyzed Denitrated Coupling Of Nitroarenes With Sulfinates

Aryl sulfones and derivatives thereof, are ubiquitous structural motifs that frequently occur in synthetic intermediates and pharmacologically active compounds. Therefore, the research on aryl sulfones is of great importance. In this dissertation, the first example of palladium-catalyzed protocol for the denitrated coupling of nitroarenes with sulfinates was developed, achieving aryl and heterocyclic sulfones in moderate to excellent yields.The results proved that a series of aryl sulfones and heterocyclic sulfone compounds were obtained with a mixture of nitroarenes(0.3 mmol), sodium sulfinates(0.6 mmol), palladacycle I(0.75 mol%) and K2CO3(1.0 equiv.) in DMSO(2 m L), 110 oC for 12 h under N2 atmosphere. The efficiency of this reaction was demonstrated by compatibility with a wide range of groups, low catalyst loading, significant green and high yields. Thus, the method represents a simple and facile procedure to access aryl and heterocyclic sulfones.