The Saponions As H5N1 Entry Inhibitors,Lauroside B And Its Isomers Of The Design,Synthesis

1. The saponions as H5N1 entry inhibitors of the design,synthesisInfluenza viruses of the highly contagious and pathogenic threatened people’s health and economy.Due to the current clinical drug for the treatment of influenza viruses have many disadvantages,such as low activity, high side effect,expensive and prone to resistance.So we need the new anti-influenza drugs,which has accelerated anti-influenza drugs research,development and synthesis.According to incomplete statistics,more than three thousand kinds of Chinese herbal medicine in Chinese Pharmacpoeia,only dozens of them an the main drug for the treatment of influenza virus.Chinese herbal medicine has the advantages of lower side effects,less adverse reaction,low resistance.Our team of reserch and development direction is virus entry inhibitors through the analysis of potential drug targets.In our group’s saponin compounds database,we found YC-72、GC-29、SGP-5 and RC-Man-3 can inhibit the H5N1 virus into the host cell.Through analysis we decide to RC-Man-3 as lead compounds design five saponin compound.Whether these compounds for H5N1 has entered the inhibitory effect remains to be further research.2. Lauroside B and its isomers of the design,synthesisIn the treatment of tumor,chenotherapy drugs play an important role,but the generation of drug resistance is a problem for the treatment of tumor.Most chemotherapy drugs,such as Taxol,vinca alkaloids,topoisomerase inhibitors,ect.,by activating the expression of tumor suppressor protein p53 to initiate tumor cell death process,but at the same time of tumor cell toxicity,can also be activated NF-κB signaling pathways,the resistant tumor cells.In melanoma NF-κB of the persistent expression is high,which cause melanoma drug resistance.By inhibiting the NF-κB signaling pathways to induce cell apoptosis,which considered chemical treatment is likely to be malignant melanoma of a breakthrough.Agela Ianaro reported megastigmane glycoside Lauroside B can inhibit the NF-κB signaling pathy activation induced apoptosis of human melanoma cells and at higher concentrations of normal epithelial cell growth did not have any effect.Our group design the synthesis of natural products Lauroside B and its isomer route.We had synthesized its isomer and aglycone,we will use them to test the activity of melanoma cells.