Synthesis Of Application Of Magnetic Nanoparticles Of Cu In Organic Synthesis

Over the several past decades, catalysts and catalytic reactions have attracted considerable attention with the aim of finding meaningful applications in the pharmaceutical andfine chemical industries. However, most homogeneous catalysts are unsuitable in the industrial field due to many practical factors that are critical for determining if it is industrially applicable. For example, the simple separation and regeneration of the catalyst from the reaction mixture is in strong demand for the cost-effective process of molecular synthesis. In the pharmaceutical industry, it is also essential to remove all traces of metal residue, which frequently interfere with the subsequent reaction and contaminate the final product. Therefore, the development of a catalyst system that can be recycled is important.We use novel magnetic nano-materials [Cu Fe O2] as catalyst, The catalytic activity of Cu Fe O2 nanoparticles was investigated in the one-pot, threecomponent reaction of 2-aminopyridines, aldehydes, and alkynes using citric acid–dimethylurea melt as a green solvent.An array of imidazo[1,2-a]pyridines were obtained in good to excellent yields. The catalytic system can be successfully reused six times with keeping its catalytic performance.We prepared Cu supported on Ni Fe2O4 nanoparticle [Ni Fe2O4-GM-Cu]. This magnetic catalyst exhibited excellent catalytic activity for the synthesis of a wide variety of 1,4-disubstituted-1,2,3-triazoles via one-pot three-component click reactions of sodium azide, non-activated terminal alkynes, and different azide precursors such as epoxides, benzyl chloride, and aryl boronic acids in water at room temperature. The prominent merits offered by this methodology are aqueous reaction medium, ambient reaction condition, high yields, wide substrate scope, easy separation of catalyst using an external magnet and efficient recycling.3-Nitro-2-phenyl-imidazo[1,2-a] pyridines are important fused heterocycles due to their potential biological activities. We first prepared magnetic nanomaterials supported cuprous chloride [Co Fe2O4@CNT-Cu]. The catalytic activity of Co Fe2O4@CNT-Cu nanoparticles was investigated reaction of 2-aminopyridines, aldehydes, and nitromethane using PEG 400 as a green solvent. Magnetic nanomaterials have high catalytic activity for synthesis of 3-nitro-2-phenyl-imidazo [1,2-a] pyridine compounds with many advantages such as simple, easy separation and recyclability.