Palladium-Catalyzed Three-Component Reaction Of Ferrocenyl Allenes, Aryl Halides And Phenols And Alcohols Reagents

Transition-metal-catalyzed multicomponent reactions play a vital role in organic synthesis. In recent years, allenes in the multicomponent reactions have received more and more attention of organic chemists, because it is convenient to construct a variety of complex compounds. Recently, our group was synthesized a series of novel structure of ferrocene allenes compounds, and applied to a variety of multicomponent reaction successfully, synthesizing a variety of compounds containing ferrocene group with high selectivity.This paper studied the three components reaction of Pd-catalysted ferrocene allenes, aromatic halide and nucleophilic reagent, nucleophilic reagents including phenol compounds and nucleophilic poor alcohols compound. Eventually, we synthesized a series of (Z)-3-ferrocene-2-aryl allyl ether compounds. Remarkably, obtained with aromatic allyl compounds and derivatives, such as esters, amines, and ethers compounds widely existing in natural products, active drug molecules, and due to their multiple functional groups can be modified, and can continue to participate in other reaction, make it become the important compounds in organic synthesis and the synthesis skeleton.