Nano CuO Catalyzed Tandem Synthesis Of (Z)-3-methyleneisoindolinones And The Synthesis Of Azoxystrobin

Heterocyclic compounds are the organic matters which contain heterocyclic structure. It commonly exists in the drug molecule and attracts great attention in organic synthesis. The efficient coupling reaction catalyzed by transition metal to form C-C and C-N bonds has been widely applied in the synthesis of heterocycles. Comparing to the Pd and other transition metal, copper is an ideal catalyst for its cheapness and lower toxicity, and approves a more efficient and greener method to synthesize the heterocyclic compounds.This thesis contains two parts:1、Nano CuO catalyzed tandem synthesis of (Z)-3-methyleneisoindolinonesA CuO-nanoparticle catalyzed efficient synthesis from 2-halobenzamides and terminal alkynes via a Sonogashira coupling to afford (Z)-3-methyleneisoindolinones in good to excellent yields was described. The reactions of 2-bromobenzamides proceeded under mild conditions without ligand in excellent yield, for 2-cholobenzamides, the ligand of 2,2’-biimidazole is essential when the reaction under mild conditions.2、Research on the synthesis of azoxystrobinWith 2-hydroxyphenylacetic acid as starting materials, we synthesized the azoxystrobin and optimized the reaction conditions. This synthesis method is simple to operate with good yields and beneficial to industrial production.