Cobalt-catalyzed The Construction Of(Z)-β-perfluoro-alkyl Enaminones And α-hexafluoroisopropyl Alkoxy Ketones

Recently, perfluoroalkyl compounds have attracted considerable interest from academic research groups as well as researchers working in industry because of their unique physical and chemical properties, and potential application. This article focus on the multicomponent radical reaction from readily available starting materials involving sequential fluoroalkylation and Kornblum-De La Mare rearrangement using cobalt salts as catalyst.This article was divided into two parts:1. The synthesis of(Z)-β-perfluoroalkyl enaminones using Co(acac)2/ TBHP.In this part, an one-pot reaction, which encompasses styrenes, perfluorinated compounds, and amines, was well developed, leading to(Z)-β-perfluoroalkyl enaminones using Co(acac)2 as catalyst and TBHP as oxidant. The methodology was also distinguished by its operational simplicity, mild conditions and insensitivity to moisture and air.2. The synthesis of α-hexafluoroisopropyl alkoxy ketones Co(acac)2/ TBHP.In this part, a multicomponent radical reaction, which encompasses styrenes, perfluorinated compounds, and 2-methoxyethanol, was well developed, leading to α-hexafluoroisopropyl alkoxy ketones using Co(acac)2 as catalyst and TBHP as oxidant. This novel approach succeeded in introducing two CF3 to the target molecules. Future research will focus on increasing the unsatisfactory yield.