Study Of The Magnetic Functional Materials Indrug Load Application Research And Analysis

Graphene oxide and carbon nanotubes have many advantages such as easy functionalization and large specific surface area. These above materials play the role in effective adsorption, loading and target transport for the drugs. Besides, these materials can be applied in different fileds including the analysis of drug ingredient, loading of anticancer drugs and drug controlled release, etc. This paper has studied on modifing graphene oxide and carbon nanotube, has prepared magnetic nano-materials with good propertiesv as well as studied the capacities of this maerial for the pharmaceutical analysis and load.(1) Graphene oxide(GO) was obtained by Hummers. NH2-Fe3O4 was prepared by hydrothermal method. NH2-Fe3O4/GO magnetic nanoparticles was prepared by functional resorcinarene. The morphologies, structures of NH2-Fe3O4/GO materials were tested by a series of methods such as SEM, XRD, FT-IR, VSM and so on. The adsorption properties to tetracycline were analyzied. Results show that when the value of p H is 5.0, the adsorption time is 75 min and the amount of NH2-Fe3O4/GO is 6.0mg, the adsorption capacity will be 31 mg/g, the adsorption rate will be above 95% and will improve the effect of the adsorption at low temperature. When the concentration of sodium borate is 0.30 mol/L, the elution rate will be above 96%.(2) The functional materials(NH2-Fe3O4/GO@PDA) were prepared by combing dopamine hydrochloride with NH2-Fe3O4/GO. The morphologies, structures of NH2-Fe3O4/GO@PDA materials were tested by a series of methods such as SEM, XRD, FT-IR, VSM and so on. The adsorption properties to ciprofloxacin were analyzied. The adsorption properties to ciprofloxacin were analyzied. As a result, when the value of p H is 7.0, the adsorption time is 60 min and the amount of NH2-Fe3O4/GO@PDA is 3.0mg, the adsorption capacity will be 43.48mg/g. When the concentration of HCl is 0.60 mol/L, the elution rate will be above 96%.(3) The nanocomposites(m-MWCNTs) were fabricated by a facile hydrothermal method. The m-MWCNTs@PDA were accquired by modifing the surface of m-MWCNTs. The performance of m-MWCNTs@PDA were characterized by methods of FTIR, XRD, SEM and VSM. The m-MWCNTs@PDA nanocomposites have slip surface uniform particle size distribution and super paramagnetic. The adsorption capacities of m-MWCNTs@PDA nanocomposites for quercetin was discussed. The best load capacity is 36.63mg/g and the load rate is above 94%. When the concentration of Na OH is 0.30 mol/L, the elution rate will be above 98%. Finally, the release test in vitro of m-MWCNTs@PDA-quercetin magnetic drugs system was conducted. The release time could last for about 12 h.